(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin:: a new ramulosin derivative from a marine-derived sterile mycelium

被引：21

作者：

El-Beih, Ahmed Atef ^{[1
]}

Kato, Hikaru ^{[1
]}

Ohta, Tomihisa ^{[1
]}

Tsukamoto, Sachiko ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa 9201192, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 06期

关键词：

6-hydroxy-5-methylramulosin; sterile mycelium; marine-derived fungus;

D O I：

10.1248/cpb.55.953

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin (1) was isolated from a culture of a sterile mycelium, which was derived from the green alga, Codium fragile, along with (-)-5-methylmellein (2), (-)-5-hydroxymethylmellein (3), and (-)-(3R,4R)-cis-4-hydroxy-5-methylmellein (4). The absolute configuration of 1 was determined by the NMR data along with the lactone sector rule by circular dichroism (CD). Compound I exhibited moderate cytotoxic activity against HeLa cells.

引用

页码：953 / 954

页数：2