(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin:: a new ramulosin derivative from a marine-derived sterile mycelium

被引：21
|
作者：
El-Beih, Ahmed Atef [1 ]
Kato, Hikaru [1 ]
Ohta, Tomihisa [1 ]
Tsukamoto, Sachiko [1 ]
机构：
[1] Kanazawa Univ, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa 9201192, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 06期
关键词：
6-hydroxy-5-methylramulosin; sterile mycelium; marine-derived fungus;
D O I：
10.1248/cpb.55.953
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin (1) was isolated from a culture of a sterile mycelium, which was derived from the green alga, Codium fragile, along with (-)-5-methylmellein (2), (-)-5-hydroxymethylmellein (3), and (-)-(3R,4R)-cis-4-hydroxy-5-methylmellein (4). The absolute configuration of 1 was determined by the NMR data along with the lactone sector rule by circular dichroism (CD). Compound I exhibited moderate cytotoxic activity against HeLa cells.
引用
收藏
页码：953 / 954
页数：2
相关论文
共 50 条
  • [1] (3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin:: a new ramulosin derivative from a marine-derived sterile mycelium (vol 55, pg 953, 2007)
    不详
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (12) : 1776 - 1776
  • [2] SYNTHESIS OF (3R,5S,6R)-2,6-DIACETOXYMETHYLCLAVAM FROM D-GALACTAL
    CHMIELEWSKI, M
    GRODNER, J
    JOURNAL OF CARBOHYDRATE CHEMISTRY, 1992, 11 (06) : 691 - 698
  • [3] Synthesis of (4R,6S,7R)-7-hydroxy-4,6-dimethyl-3-nonanone and (3R,5S,6R)-6-hydroxy-3,5-dimethyl-2-octanone
    Sabitha, Gowravaram
    Srinivas, Chitti
    Maruthi, Chittapragada
    Yadav, Jhillu Singh
    TETRAHEDRON-ASYMMETRY, 2011, 22 (24) : 2071 - 2079
  • [4] WORKSPACE SYNTHESIS OF 3R, 4R, 5R AND 6R ROBOTS.
    Tsai, Y.C.
    Soni, A.H.
    1600, (20):
  • [5] Stereoselective synthesis of (5S,6S)- and (5S,6R)-aza-muricatacin from an L-glutamic acid derivative
    Andrés, JM
    de Elena, N
    Pedrosa, R
    Pérez-Encabo, A
    TETRAHEDRON-ASYMMETRY, 2001, 12 (10) : 1503 - 1509
  • [6] Short practical synthesis of (3R,4R,5R,6R)-tetrahydroxyazepane and (3S,4S,5S,6S)-tetrahydroxyazepane from D- and L-chiro-inositol, respectively
    Painter, GF
    Falshaw, A
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (07): : 1157 - 1159
  • [7] Molecular and crystal structures of 4′-hydroxy derivative of (3R,6R)-3-methyl-6-isopropyl-2-(4-phenylbenzylidene)cyclohexanone
    L. A. Kutulya
    V. I. Kulishov
    S. V. Shishkina
    A. S. Tolochko
    A. D. Roshal’
    O. V. Shishkin
    Crystallography Reports, 2008, 53 : 455 - 461
  • [8] Synthesis of (4R,6S,7R)-7-hydroxy-4,6-dimethyl-3-nonanone and (3R,5S,6R)-6-hydroxy-3,5-dimethyl-2-octanone, the pheromone components of the bostrychid beetle, Dinoderus bifoveolatus
    Masuda, Y
    Fujita, K
    Mori, K
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2003, 67 (08) : 1744 - 1750
  • [9] 5-{(2S,3R,4S,5S,6R)-3,4-dihydroxy-6-hydroxymethyl-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydropyran-2-yloxy]tetrahydropyran-2-yloxy}-7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one monohydrate
    Chen, Yuzhen
    Wang, Airong
    Gao, Haiyan
    Niu, Shengyang
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1901 - U3554
  • [10] (5S,6R)-5-Methyl-6-phenyl-4-propyl-1,3,4-oxadiazinane-2-thione
    Kocher, Joshua L.
    Edler, Kate L.
    Bohling, Barbara A.
    Nora, George P.
    Stafford, Carrie
    Hitchcock, Shawn R.
    Ferrence, Gregory M.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1421 - U3134
12345