Total synthesis of (+)-homopumiliotoxin 223G

被引：26

作者：

Aoyagi, S ^{[1
]}

Hasegawa, Y ^{[1
]}

Hirashima, S ^{[1
]}

Kibayashi, C ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(98)00082-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new practical route for the first total synthesis of (+)-homopumiliotoxin 223G is described, in which the palladium-catalyzed carbonylation of the vinyl iodide, leading to efficient construction of the quinolizidine nucleus incorporating the (Z)-alkylidene side chain, is the key strategic element. Another key feature of this synthesis involves the Lewis acid-induced chelation-controlled propargylation using the allenylsilane with complete diastereoselectivity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2149 / 2152

页数：4

共 17 条

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