Is leukocytosis a predictor of mortality in severe pertussis infection?

被引：126
作者：
Pierce, C
Klein, N
Peters, M
机构：
[1] Inst Child Hlth, Portex Dept Anaesthesia Intens Therapy & Resp Med, London WC1N 3EH, England
[2] Great Ormond St Hosp Sick Children, Paediat Intens Care Unit, London WC1N 3JH, England
[3] Inst Child Hlth, Immunobiol Unit, London WC1N 3EH, England
来源：
INTENSIVE CARE MEDICINE | 2000年 / 26卷 / 10期
关键词：
pertussis; whooping cough; respiratory failure; pulmonary hypertension; outcome; leukocytosis;
D O I：
10.1007/s001340000587
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Bordetella pertussis causing severe respiratory failure in infants that, is unresponsive to treatment is well described. Pulmonary hypertension is a prominent feature of such cases. In this series of 13 critically ill infants with B. pertussis, hyperleukocytosis (> 100 x 10(9)/l) was an independent predictor of death. We suggest that such extreme leukocytosis may contribute to disease severity via the formation of aggregates in the pulmonary vasculature.
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收藏
页码：1512 / 1514
页数：3
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