Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice

被引：33

作者：

Dutta, Noton K. ^{[1
]}

Pinn, Michael L. ^{[1
]}

Karakousis, Petros C. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Ctr TB Res, Baltimore, MD 21205 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Mycobacterium tuberculosis; metformin; standard first-line regimen; BALB/c; bactericidal; sterilizing; host-directed therapy; relapse; cure; Denver regimen; HOST-DIRECTED THERAPIES; TUBERCULOSIS; RIFAMPIN; THIORIDAZINE; MOXIFLOXACIN; COMBINATION; MOUSE;

D O I：

10.1128/AAC.00652-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Preliminary preclinical and observational studies suggest the potential utility of metformin as an adjunctive, host-directed agent for treatment of tuberculosis (TB). In this study, we sought to investigate the bactericidal and sterilizing activities of human-like exposures of metformin when given in combination with the first-line regimen against chronic tuberculosis in BALB/c mice. Mice receiving metformin adjunctive therapy had similar lung bacillary burdens with control mice during treatment, and the proportion of mice with microbiological relapse was similar between the two groups.

引用

页数：4

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