The Dual Role of Zonula Occludens (ZO) Proteins

被引：183

作者：

Bauer, H. ^{[1
]}

Zweimueller-Mayer, J. ^{[1
]}

Steinbacher, P. ^{[1
]}

Lametschwandtner, A. ^{[1
]}

Bauer, H. C. ^{[1
,2
]}

机构：

[1] Salzburg Univ, Dept Organism Biol, A-5020 Salzburg, Austria

[2] Paracelsus Private Med Univ, Unit Appl Cell Biol, Salzburg, Austria

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2010年

关键词：

TIGHT-JUNCTION PROTEIN; LARGE TUMOR-SUPPRESSOR; TRANSCRIPTION FACTOR ZONAB/DBPA; CELLS LACKING EXPRESSION; GUANYLATE KINASE DOMAINS; ATTACHMENT FACTOR-B; HUMAN BREAST-CANCER; EPITHELIAL-CELLS; PDZ-DOMAIN; INTRAMOLECULAR INTERACTION;

D O I：

10.1155/2010/402593

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton. ZO proteins belong to the large family of membrane-associated guanylate kinase (MAGUK)-like proteins comprising a number of subfamilies based on domain content and sequence similarity. Besides their structural function at cell-cell contacts, ZO proteins appear to participate in the regulation of cell growth and proliferation. Detailed molecular studies have shown that ZO proteins exhibit conserved functional nuclear localization and nuclear export motifs within their amino acid sequence. Further, ZO proteins interact with dual residency proteins localizing to the plasma membrane and the nucleus. Although the nuclear targeting of ZO proteins has well been described, many questions concerning the biological significance of this process have remained open. This review focuses on the dual role of ZO proteins, being indispensable structural components at the junctional site and functioning in signal transduction pathways related to gene expression and cell behavior.

引用

页数：11

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