Isolation and characterisation of the sesquiterpene lactones from Lactuca sativa L var. anagustata

被引：36

作者：

Han, Yi-Feng ^{[1
]}

Cao, Gui-Xiu ^{[1
]}

Gao, Xiao-Jing ^{[1
]}

Xia, Min ^{[1
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Zhejiang, Peoples R China

来源：

FOOD CHEMISTRY | 2010年 / 120卷 / 04期

基金：

美国国家科学基金会;

关键词：

Lactuca sativa L var. anagustata; Compositae; Sesquiterpene lactone; Cytotoxicity; Antioxidation; CONSTITUENTS; GLYCOSIDES;

D O I：

10.1016/j.foodchem.2009.11.056

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Lactuca sativa L var. anagustata is widely used as both a delicious vegetable and a traditional medicine in China. Chemical investigation of the methanolic extract of L. sativa L var. anagustata has now led to the isolation of three new sesquiterpenes, together with eight known ones. All the compounds were isolated by chromatography on a silica gel column and preparative thin-layer chromatography (PTLC). Their structures were elucidated by means of spectroscopic methods, including 2D-NMR experiments. Cytotoxicity of the new compounds was assayed against selected cancer cell lines, including the human epithelial carcinoma (HeLa) and human colon carcinoma (HCT-116) cell lines. Radical-scavenging activities of the seven compounds were determined by DPPH radical-scavenging assay. (C) 2009 Elsevier Ltd. All Fights reserved.

引用

页码：1083 / 1088

页数：6

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