The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer

被引：0

作者：

Wan Liang-Qin ^{[1
]}

Tan Yan ^{[1
]}

Jiang Miao ^{[2
]}

Hua Qian ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing 100029, Peoples R China

[2] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 100029, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Lung cancer; Tumor microenvironment; Tumor-associated macrophages; Traditional Chinese medicine (TCM) monomer; Immunotherapy; RHIZOMA-PARIDIS SAPONINS; ANTITUMOR-ACTIVITY; TEA POLYPHENOLS; APOPTOTIC INDEX; DOWN-REGULATION; BLACK TEA; IN-VITRO; TRIPTOLIDE; GROWTH; PROLIFERATION;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Non-small cell lung cancer (NSCLC) accounts for 80%-85% of all lung malignancies and good diagnosis and prognosis of NSCLC are critical to the increase of its survival rate. Tumor-associated macrophages (TAM) abundantly present in numerous cancer types, and the role of TAMs in tumor biology and their prognostic value in cancer become major topics of interest. After various stimulations in the tumor microenvironment, TAMs develop into a M1 (tumor-inhibitory) phenotype or M2 (tumor-promoting) phenotype. Recent studies show that traditional Chinese medicine (TCM) monomers have markedly inhibitory actions for NSCLC through M1/M2 modulation. Due to the TCM monomers mainly covered five categories, i.e. terpenoids, flavonoids, polysaccharides, natural polyphenols, and alkaloids. Thus, we will discuss the regulation of TCM monomers on TAM involve in these five parts in this review. In addition, the potential role of TAMs as therapeutic targets will be discussed.

引用

页码：729 / 737

页数：9

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