Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract

被引：0

作者：

El-Shahat, Abd El-Rahman ^{[1
]}

Gabr, Attia ^{[2
]}

Meki, Abdel-Raheim ^{[3
]}

Mehana, El-Saed ^{[4
]}

机构：

[1] Cairo Univ, Fac Med, Dept Anat, Cairo, Egypt

[2] Suez Canal Univ, Dept Pharmacol, Fac Med, Ismailia, Egypt

[3] Assiut Univ, Dept Biochem, Fac Med, Assiut, Egypt

[4] Univ Alexandria, Dept Pathol, Fac Vet Med, Alexandria, Egypt

来源：

INTERNATIONAL JOURNAL OF MORPHOLOGY | 2009年 / 27卷 / 03期

关键词：

Rat Testes; Cadmium toxicity; Green tea extract; Lipid peroxides; Glutathione; HEPATIC LIPID-PEROXIDATION; GLUTATHIONE; DAMAGE; ANTIOXIDANT; TOXICITY; SELENIUM; METALLOTHIONEIN; ZINC;

D O I：

暂无

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Cadmium (Cd), is an environmental and industrial pollutant that affects the male reproductive system. Cd induces its effect by affecting tissue antioxidant enzyme systems. Green tea extract (GTE) is an antioxidant and free radicals scavenger and has a chelating property. The purpose of this study was to investigate the protective effect of GTE against testes damage induced by Cd. Four groups of male rats, were utilized as following: Controls, GTE treated, Cd treated and Cd + GTE, treated rats at the same doses. The rats received GTE and or Cd orally in drinking water. After 5 weeks, the animals were sacrificed and testes were removed for microscopic and Biochemical evaluation. The levels of lipid peroxides (LPO) and glutathione (GSH) were detected in the tissue homogenates of rat testes. The current study showed marked morphological changes in the form of swelling, congestion, hemorrhage and necrosis in testes of rats treated with Cd alone. However, the rats treated with Cd+GTE showed milder edema, congestion and minute foci of necrosis in the testes. The LPO levels were significantly higher as compared to control and of GSH were significantly lower in Cd-treated rats but when GTE was co-administrated with Cd, there was an effective reduction in oxidative stress as shown by a significant rise of GSH level. In conclusion, the rats received GTE + Cd could enhance antioxidant/detoxification system which consequently reduced the oxidative stress in rat testes. The beneficial effect of GTE is thus potentially reducing Cd toxicity and tissue damage.

引用

页码：757 / 764

页数：8