Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies

被引：38

作者：

Cascella, Marco ^{[1
]}

Palma, Giuseppe ^{[2
]}

Barbieri, Antonio ^{[2
]}

Bimonte, Sabrina ^{[1
]}

Amruthraj, Nagoth Joseph ^{[2
,3
]}

Muzio, Maria Rosaria ^{[4
]}

del Vecchio, Vitale ^{[2
]}

Rea, Domenica ^{[2
]}

Falco, Michela ^{[2
]}

Luciano, Antonio ^{[2
]}

Arra, Claudio ^{[2
]}

Cuomo, Arturo ^{[1
]}

机构：

[1] Fdn G Pascale, IRCCS, Ist Nazl Tumori, Div Anesthesia & Pain Med, Via Mariano Semmola, I-80131 Naples, Italy

[2] Fdn G Pascale, IRCCS, Ist Nazl Tumori, SSD Sperimentaz Anim, I-80131 Naples, Italy

[3] Univ Study Campania Luigi Vanvitelli, Dept Cardiovasc Med, Chair Nephrol, Clin Expt & Med Sci, I-81100 Caserta, Italy

[4] UOMI Maternal & Infant Hlth, Asl NA SUD 3, Div Infantile Neuropsychiat, Via Marconi, I-80059 Naples, Italy

来源：

NUTRIENTS | 2017年 / 9卷 / 06期

关键词：

Nigella sativa; Thymoquinone; natural compounds; chemotherapy-induced nephrotoxicity; CISPLATIN-INDUCED NEPHROTOXICITY; DOXORUBICIN-INDUCED NEPHROTOXICITY; GENTAMICIN-INDUCED NEPHROTOXICITY; FANCONI SYNDROME; PROTECTIVE ROLE; IN-VITRO; TOXICITY; OIL; IFOSFAMIDE; RATS;

D O I：

10.3390/nu9060625

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore, new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role in combating chemotherapy-induced nephrotoxicity. AIM: To analyze and report the outcome of experimental animal studies on the protective effects of NS/TQ on chemotherapy-associated kidney complications. Design: Standard systematic review and narrative synthesis. Data Sources: MEDLINE, EMBASE databases were searched for relevant articles published up to March 2017. Additionally, a manual search was performed. Criteria for a study's inclusion were: conducted in animals, systematic reviews and meta-analysis, containing data on nephroprotective effects of NS/TQ compared to a placebo or other substance. All strains and genders were included. Results: The database search yielded 71 studies, of which 12 (cisplatin-induced nephrotoxicity 8; methotrexate-induced nephrotoxicity 1; doxorubicin-induced nephrotoxicity 2; ifosfamide-induced nephrotoxicity 1) were included in this review. Conclusions: Experimental animal studies showed the protective effect of NS, or TQ, on chemotherapy-induced nephrotoxicity. These effects are caused by decreasing lipid peroxidation and increasing activity of antioxidant enzymes in renal tissue of chemotherapy-treated animals.

引用

页数：14

共 68 条

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