Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe

被引：0

作者：

Forns, Joan ^{[1
,2
]}

Sunyer, Jordi ^{[1
,2
,3
,4
]}

Garcia-Esteban, Raquel ^{[1
,3
]}

Porta, Daniela ^{[5
]}

Ghassabian, Akhgar ^{[6
]}

Giorgis-Allemand, Lise ^{[7
,8
]}

Gong, Tong ^{[9
]}

Gehring, Ulrike ^{[10
]}

Sorensen, Mette ^{[11
]}

Standl, Marie ^{[12
]}

Sugiri, Dorothee ^{[13
]}

Almqvist, Catarina ^{[9
,14
]}

Andiarena, Ainara ^{[15
,16
]}

Badaloni, Chiara ^{[5
]}

Beelen, Rob ^{[10
]}

Berdel, Dietrich ^{[17
]}

Cesaroni, Giulia ^{[5
]}

Charles, Marie-Aline ^{[18
,19
]}

Eriksen, Kirsten Thorup ^{[11
]}

Estarlich, Marisa ^{[3
,20
]}

Fernandez, Mariana F. ^{[3
,21
,22
]}

Forhan, Anne ^{[18
,19
]}

Jaddoe, Vincent W. V. ^{[23
,24
,25
]}

Korek, Michal ^{[26
]}

Lichtenstein, Paul ^{[9
]}

Lertxundi, Aitana ^{[16
,27
]}

Lopez-Espinosa, Maria-Jose ^{[3
,20
]}

Markevych, Iana ^{[12
,28
]}

de Nazelle, Audrey ^{[29
]}

Raaschou-Nielsen, Ole ^{[11
,30
]}

Nieuwenhuijsen, Mark ^{[1
,2
]}

Perez-Lobato, Rocio ^{[21
,22
]}

Philippat, Claire ^{[7
,8
]}

Slama, Remy ^{[7
,8
]}

Tiesler, Carla M. T. ^{[12
,31
]}

Verhulst, Frank C. ^{[6
]}

von Berg, Andrea ^{[17
]}

Vrijkotte, Tanja ^{[32
]}

Andersen, Anne-Marie Nybo ^{[33
]}

Heude, Barbara ^{[18
,19
]}

Kramer, Ursula ^{[13
]}

Heinrich, Joachim ^{[12
,28
]}

Tiemeier, Henning ^{[6
]}

Forastiere, Francesco ^{[5
]}

Pershagen, Goran ^{[26
,34
]}

Brunekreef, Bert ^{[10
,35
]}

Guxens, Monica ^{[1
,3
,4
,6
]}

机构：

[1] ISGlobal, Barcelona, Spain

[2] Hosp del Mar, Res Inst, Barcelona, Spain

[3] Spanish Consortium Res Epidemiol Publ Hlth CIBERE, Valencia, Spain

[4] Pompeu Fabra Univ, Barcelona, Spain

[5] ASL Roma 1, Lazio Reg Hlth Serv, Dept Epidemiol, Rome, Italy

[6] Erasmus MC, Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands

[7] Univ Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, IAB, F-38000 Grenoble, France

[8] Inserm, U1209, IAB, Team Environm Epidemiol Appl Reprod & Resp Hlth, F-38000 Grenoble, France

[9] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[10] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands

[11] Danish Canc Soc Res Ctr, Strandboulevarden, Denmark

[12] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Munich, Germany

[13] Leibniz Res Inst Environm Med, IUF, Dusseldorf, Germany

[14] Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Lung & Allergy Unit, Stockholm, Sweden

[15] Univ Basque Country, UPV EHU, Fac Psychol, San Sebastian, Spain

[16] BioDonostia Hlth Res Inst, San Sebastian, Basque Country, Spain

[17] Marien Hosp, Dept Pediat, Res Inst, Wesel, Germany

[18] INSERM, UMR1153, Epidemiol & Biostat Sorbonne Paris Cite Ctr CRESS, Dev Origins Hlth & Dis ORCHAD Team, Villejuif, France

[19] Paris Descartes Univ, Paris, France

[20] Univ Valencia, Univ Jaume I, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain

[21] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain

[22] Univ Granada, Granada, Spain

[23] Erasmus Med Centre, Sophia Childrens Hosp, Generat Study Grp R, Rotterdam, Netherlands

[24] Erasmus Med Centre, Sophia Childrens Hosp, Dept Epidemiol, Rotterdam, Netherlands

[25] Erasmus Med Centre, Sophia Childrens Hosp, Dept Pediat, Rotterdam, Netherlands

[26] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[27] Univ Basque Country, Fac Med, Leioa, Basque Country, Spain

[28] Ludwig Maximilians Univ Munchen, Inst Occupat Social & Environm Med, Munich, Germany

[29] Imperial Coll London, Ctr Environm Policy, London, England

[30] Aarhus Univ, Dept Environm Sci, Roskilde, Denmark

[31] Ludwig Maximilians Univ Munchen, Dr von Hauner Childrens Hosp, Div Metab Dis & Nutr Med, Munich, Germany

[32] UVA, Acad Med Ctr, Dept Publ Hlth, Amsterdam, Netherlands

[33] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[34] Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden

[35] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

来源：

EPIDEMIOLOGY | 2018年 / 29卷 / 05期

关键词：

attention deficit disorder with hyperactivity; child development; environmental pollution; longitudinal studies; meta-analysis; nitrogen oxides; particulate matter; prospective studies; POLYCYCLIC AROMATIC-HYDROCARBONS; USE REGRESSION-MODELS; DEFICIT/HYPERACTIVITY DISORDER; PSYCHOTROPIC MEDICATIONS; BEHAVIORAL-PROBLEMS; PM2.5; ABSORBENCY; COHORT PROFILE; PAH EXPOSURE; CORD BLOOD; NO2;

D O I：

10.1097/EDE.0000000000000874

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Exposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29,127 mother-child pairs. Methods: Air pollution concentrations (nitrogen dioxide [NO2] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3-10 years of age. We classified children as having ADHD symptoms within the borderline/clinical range and within the clinical range using validated cutoffs. We combined all adjusted area-specific effect estimates using random-effects meta-analysis and multiple imputations and applied inverse probability-weighting methods to correct for loss to follow-up. Results: We classified a total of 2,801 children as having ADHD symptoms within the borderline/clinical range, and 1,590 within the clinical range. Exposure to air pollution during pregnancy was not associated with a higher odds of ADHD symptoms within the borderline/clinical range (e.g., adjusted odds ratio [OR] for ADHD symptoms of 0.95, 95% confidence interval [CI] = 0.89, 1.01 per 10 mu g/m(3) increase in NO2 and 0.98, 95% CI = 0.80, 1.19 per 5 mu g/m(3) increase in PM2.5). We observed similar associations for ADHD within the clinical range. Conclusions: There was no evidence for an increase in risk of ADHD symptoms with increasing prenatal air pollution levels in children aged 3-10 years. See video abstract at, http://links.lww.com/EDE/B379.

引用

页码：618 / 626

页数：9

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