11C-PiB PET ABri Imaging in Worster-Drought Syndrome (Familial British Dementia): A Case Report

被引：10

作者：

Villemagne, Victor L. ^{[1
,2
]}

Pike, Kerryn ^{[1
,2
]}

Pejoska, Svetlana ^{[1
]}

Boyd, Alison ^{[3
]}

Power, Margaret ^{[2
]}

Jones, Gareth ^{[1
]}

Masters, Colin L. ^{[2
]}

Rowe, Christopher C. ^{[1
]}

机构：

[1] Austin Hlth, Dept Nucl Med, Ctr PET, Heidelberg, Vic 3084, Australia

[2] Univ Melbourne, Mental Hlth Res Inst, Melbourne, Vic, Australia

[3] Univ Melbourne, Dept Pathol, Australian Natl CJD Registry, Parkville, Vic 3052, Australia

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 19卷 / 02期

关键词：

Amyloid; brain imaging; Familial British Dementia; PiB; positron emission tomography; Worster-Drought syndrome; STOP-CODON MUTATION; BRAIN; BRI; DEPOSITION; BINDING;

D O I：

10.3233/JAD-2010-1241

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain amyloid imaging is becoming an essential tool for the pre-mortem evaluation of Alzheimer's disease (AD). This study explores the pattern of C-11-PiB retention in a subject with Worster-Drought syndrome (WDS). A 55 year-old male carrier of the WDS gene mutation with mild signs of ataxia and subtle cognitive impairment underwent MRI and C-11-PiB-PET studies. Brain PiB regional distribution was compared to those from cohorts of healthy controls and AD patients. While no significant cortical C-11-PiB retention was present, a high degree of cerebellar C-11-PiB retention was observed in a genetically confirmed carrier of the WDS gene. We speculate that the sparsity of A(Bri) plaques in the neocortex together with its high deposition in the cerebellum, might explain the observed pattern of C-11-PiB retention.

引用

页码：423 / 428

页数：6

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