Virulence Factors in Hypervirulent Klebsiella pneumoniae

被引：200

作者：

Zhu, Jie ^{[1
]}

Wang, Tao ^{[1
]}

Chen, Liang ^{[2
,3
]}

Du, Hong ^{[1
]}

机构：

[1] Soochow Univ, Dept Clin Lab, Affiliated Hosp 2, Suzhou, Peoples R China

[2] Hackensack Meridian Hlth Ctr Discovery & Innovat, Nutley, NJ USA

[3] Hackensack Meridian Sch Med, Dept Med Sci, Nutley, NJ USA

来源：

FRONTIERS IN MICROBIOLOGY | 2021年 / 12卷

关键词：

Klebsiella pneumoniae; hypermucoviscous; capsule; siderophores; virulence factors; hypervirulence; CAPSULAR POLYSACCHARIDE SYNTHESIS; PYOGENIC LIVER-ABSCESS; OUTER-MEMBRANE PROTEIN; ESCHERICHIA-COLI; SEROTYPE K1; IRON-ACQUISITION; HYPERMUCOVISCOSITY PHENOTYPE; CLINICAL-MANIFESTATIONS; GENOMIC HETEROGENEITY; EMERGING DISEASE;

D O I：

10.3389/fmicb.2021.642484

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver abscess, pneumonia, meningitis, and endophthalmitis. It utilizes a battery of virulence factors for survival and pathogenesis, such as capsule, siderophores, lipopolysaccharide, fimbriae, outer membrane proteins, and type 6 secretion system, of which the former two are dominant. This review summarizes these hvKP-associated virulence factors in order to understand its molecular pathogenesis and shed light on new strategies to improve the prevention, diagnosis, and treatment of hvKP-causing infection.

引用

页数：14

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