Thrombocytopathies: Not Just Aggregation Defects-The Clinical Relevance of Procoagulant Platelets

被引：19
作者：
Aliotta, Alessandro [1 ,2 ,3 ]
Calderara, Debora Bertaggia [1 ,2 ,3 ]
Zermatten, Maxime G. [1 ,2 ,3 ]
Marchetti, Matteo [1 ,2 ,3 ,4 ]
Alberio, Lorenzo [1 ,2 ,3 ]
机构：
[1] Lausanne Univ Hosp CHUV, Div Hematol, Hemostasis & Platelet Res Lab, CH-1010 Lausanne, Switzerland
[2] Lausanne Univ Hosp CHUV, Cent Hematol Lab, CH-1010 Lausanne, Switzerland
[3] Univ Lausanne UNIL, CH-1010 Lausanne, Switzerland
[4] Hop Nyon, Serv Med Interne, CH-1260 Nyon, Switzerland
来源：
JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 05期
基金：
瑞士国家科学基金会;
关键词：
thrombocytopathy; platelet disorders; procoagulant platelets; activation endpoints; VON-WILLEBRAND-DISEASE; BERNARD-SOULIER-SYNDROME; STORAGE POOL DEFICIENCY; GLYCOPROTEIN-IB-ALPHA; MONITORING THROMBIN GENERATION; FLOW-CYTOMETRIC ANALYSIS; COATED-PLATELETS; PHOSPHATIDYLSERINE EXPOSURE; GLANZMANNS-THROMBASTHENIA; INCREASED MORTALITY;
D O I：
10.3390/jcm10050894
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in thrombocytopathies variously characterized by defects of their adhesive and procoagulant activation endpoints. In this review, we summarize the traditional platelet defects in adhesion, secretion, and aggregation. In addition, we review the current knowledge about procoagulant platelets, focusing on their role in bleeding or thrombotic pathologies and their pharmaceutical modulation. Procoagulant activity is an important feature of platelet activation, which should be specifically evaluated during the investigation of a suspected thrombocytopathy.
引用
收藏
页码：1 / 28
页数：28
相关论文
共 271 条
  • [1] Procoagulant Platelets Form an α-Granule Protein-covered "Cap" on Their Surface That Promotes Their Attachment to Aggregates
    Abaeva, Anastasia A.
    Canault, Matthias
    Kotova, Yana N.
    Obydennyy, Sergey I.
    Yakimenko, Alena O.
    Podoplelova, Nadezhda A.
    Kolyadko, Vladimir N.
    Chambost, Herve
    Mazurov, Aleksei V.
    Ataullakhanov, Fazoil I.
    Nurden, Alan T.
    Alessi, Marie-Christine
    Panteleev, Mikhail A.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (41) : 29621 - 29632
  • [2] Diagnostic utility of the ISTH bleeding assessment tool in patients with suspected platelet function disorders
    Adler, Marcel
    Kaufmann, Jonas
    Alberio, Lorenzo
    Nagler, Michael
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2019, 17 (07) : 1104 - 1112
  • [3] Procoagulant platelets: generation, function, and therapeutic targeting in thrombosis
    Agbani, Ejaife O.
    Poole, Alastair W.
    [J]. BLOOD, 2017, 130 (20) : 2171 - 2179
  • [4] Membrane Ballooning in Aggregated Platelets is Synchronised and Mediates a Surge in Microvesiculation
    Agbani, Ejaife O.
    Williams, Christopher M.
    Hers, Ingeborg
    Poole, Alastair W.
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [5] Coordinated Membrane Ballooning and Procoagulant Spreading in Human Platelets
    Agbani, Ejaife O.
    van den Bosch, Marion T. J.
    Brown, Ed
    Williams, Christopher M.
    Mattheij, Nadine J. A.
    Cosemans, Judith M. E. M.
    Collins, Peter W.
    Heemskerk, Johan W. M.
    Hers, Ingeborg
    Poole, Alastair W.
    [J]. CIRCULATION, 2015, 132 (15) : 1414 - 1424
  • [6] Surface expression and functional characterization of α-granule factor V in human platelets:: effects of ionophore A23187, thrombin, collagen, and convulxin
    Alberio, L
    Safa, O
    Clemetson, KJ
    Esmon, CT
    Dale, GL
    [J]. BLOOD, 2000, 95 (05) : 1694 - 1702
  • [7] Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation
    Alberio, Lorenzo
    Ravanat, Catherine
    Hechler, Beatrice
    Mangin, Pierre H.
    Lanza, Francois
    Gachet, Christian
    [J]. THROMBOSIS AND HAEMOSTASIS, 2017, 117 (06) : 1101 - 1114
  • [8] Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders
    Alessi, Marie-Christine
    Sie, Pierre
    Payrastre, Bernard
    [J]. JOURNAL OF CLINICAL MEDICINE, 2020, 9 (03)
  • [9] Characterization of Procoagulant COAT Platelets in Patients with Glanzmann Thrombasthenia
    Aliotta, Alessandro
    Krusi, Manuel
    Calderara, Debora Bertaggia
    Zermatten, Maxime G.
    Gomez, Francisco J.
    Sauvage, Ana P. Batista Mesquita
    Alberio, Lorenzo
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (24) : 1 - 15
  • [10] Sodium-Calcium Exchanger Reverse Mode Sustains Dichotomous Ion Fluxes Required for Procoagulant COAT Platelet Formation
    Aliotta, Alessandro
    Bertaggia Calderara, Debora
    Zermatten, Maxime G.
    Alberio, Lorenzo
    [J]. THROMBOSIS AND HAEMOSTASIS, 2021, 121 (03) : 309 - 321
12345678910