Thrombocytopathies: Not Just Aggregation Defects-The Clinical Relevance of Procoagulant Platelets

被引：20
作者：
Aliotta, Alessandro [1 ,2 ,3 ]
Calderara, Debora Bertaggia [1 ,2 ,3 ]
Zermatten, Maxime G. [1 ,2 ,3 ]
Marchetti, Matteo [1 ,2 ,3 ,4 ]
Alberio, Lorenzo [1 ,2 ,3 ]
机构：
[1] Lausanne Univ Hosp CHUV, Div Hematol, Hemostasis & Platelet Res Lab, CH-1010 Lausanne, Switzerland
[2] Lausanne Univ Hosp CHUV, Cent Hematol Lab, CH-1010 Lausanne, Switzerland
[3] Univ Lausanne UNIL, CH-1010 Lausanne, Switzerland
[4] Hop Nyon, Serv Med Interne, CH-1260 Nyon, Switzerland
来源：
JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 05期
基金：
瑞士国家科学基金会;
关键词：
thrombocytopathy; platelet disorders; procoagulant platelets; activation endpoints; VON-WILLEBRAND-DISEASE; BERNARD-SOULIER-SYNDROME; STORAGE POOL DEFICIENCY; GLYCOPROTEIN-IB-ALPHA; MONITORING THROMBIN GENERATION; FLOW-CYTOMETRIC ANALYSIS; COATED-PLATELETS; PHOSPHATIDYLSERINE EXPOSURE; GLANZMANNS-THROMBASTHENIA; INCREASED MORTALITY;
D O I：
10.3390/jcm10050894
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in thrombocytopathies variously characterized by defects of their adhesive and procoagulant activation endpoints. In this review, we summarize the traditional platelet defects in adhesion, secretion, and aggregation. In addition, we review the current knowledge about procoagulant platelets, focusing on their role in bleeding or thrombotic pathologies and their pharmaceutical modulation. Procoagulant activity is an important feature of platelet activation, which should be specifically evaluated during the investigation of a suspected thrombocytopathy.
引用
收藏
页码：1 / 28
页数：28
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