Ursolic Acid Inhibits Superoxide Production in Activated Neutrophils and Attenuates Trauma-Hemorrhage Shock-Induced Organ Injury in Rats

被引：15
作者：
Hwang, Tsong-Long [1 ,2 ]
Shen, Hsin-I [1 ]
Liu, Fu-Chao [3 ,4 ]
Tsai, Hsin-I [3 ,4 ]
Wu, Yang-Chang [5 ,6 ,7 ]
Chang, Fang-Rong [7 ]
Yu, Huang-Ping [3 ,4 ]
机构：
[1] Chang Gung Univ, Coll Med, Sch Tradit Med, Grad Inst Nat Prod, Taoyuan, Taiwan
[2] Chang Gung Univ, Healthy Aging Res Ctr, Chinese Herbal Med Res Team, Taoyuan, Taiwan
[3] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan, Taiwan
[4] Chang Gung Univ, Coll Med, Taoyuan, Taiwan
[5] China Med Univ, Coll Pharm, Sch Pharm, Taichung, Taiwan
[6] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung, Taiwan
[7] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung, Taiwan
来源：
PLOS ONE | 2014年 / 9卷 / 10期
关键词：
D O I：
10.1371/journal.pone.0111365
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Neutrophil activation is associated with the development of organ injury after trauma-hemorrhagic shock. In the present study, ursolic acid inhibited the superoxide anion generation and elastase release in human neutrophils. Administration of ursolic acid attenuated trauma-hemorrhagic shock-induced hepatic and lung injuries in rats. In addition, administration of ursolic acid attenuated the hepatic malondialdehyde levels and reduced the plasma aspartate aminotransferase and alanine aminotransferase levels after trauma-hemorrhagic shock. In conclusion, ursolic acid, a bioactive natural compound, inhibits superoxide anion generation and elastase release in human neutrophils and ameliorates trauma-hemorrhagic shock-induced organ injury in rats.
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页数：5
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