Evidence for Drug Release from a Metalla-Cage Delivery Vector Following Cellular Internalisation

被引：115

作者：

Zava, Olivier ^{[2
]}

Mattsson, Johan ^{[1
]}

Therrien, Bruno ^{[1
]}

Dyson, Paul J. ^{[2
]}

机构：

[1] Univ Neuchatel, Inst Chim, CH-2009 Neuchatel, Switzerland

[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 05期

关键词：

anticancer agents; drug delivery; in vitro assays; ruthenium; supramolecular chemistry; OVARIAN-CARCINOMA CELLS; ANTICANCER AGENT; RUTHENIUM; ENCAPSULATION; COMPLEX; BINDING; CANCER;

D O I：

10.1002/chem.200903216

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Figure Presented A new journey in the Trojan horse odyssey: Encapsulation of a fluorescent guest in the hydrophobic cavity of a cationic metalla-prismatic cage shows that the guest is released following cellular uptake, which illustrates the potential of this kind of water-soluble metalla-cage to act as drug carrier. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1428 / 1431

页数：4

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