Evidence for Drug Release from a Metalla-Cage Delivery Vector Following Cellular Internalisation

被引：115
作者：
Zava, Olivier [2 ]
Mattsson, Johan [1 ]
Therrien, Bruno [1 ]
Dyson, Paul J. [2 ]
机构：
[1] Univ Neuchatel, Inst Chim, CH-2009 Neuchatel, Switzerland
[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 05期
关键词：
anticancer agents; drug delivery; in vitro assays; ruthenium; supramolecular chemistry; OVARIAN-CARCINOMA CELLS; ANTICANCER AGENT; RUTHENIUM; ENCAPSULATION; COMPLEX; BINDING; CANCER;
D O I：
10.1002/chem.200903216
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Figure Presented A new journey in the Trojan horse odyssey: Encapsulation of a fluorescent guest in the hydrophobic cavity of a cationic metalla-prismatic cage shows that the guest is released following cellular uptake, which illustrates the potential of this kind of water-soluble metalla-cage to act as drug carrier. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1428 / 1431
页数：4
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