LOSARTAN POTASSIUM DISSOLUTION TEST FOR DRUG RELEASE EVALUATION IN PHARMACEUTICAL CAPSULES USING HPLC AND UV SPECTROPHOTOMETRY

被引：18

作者：

Bonfilio, Rudy ^{[1
]}

Mendonca, Taciane Ferreira ^{[1
]}

Pereira, Gislaine Ribeiro ^{[1
]}

de Araujo, Magali Benjamim ^{[1
]}

Teixeira Tarley, Cesar Ricardo ^{[2
]}

机构：

[1] Univ Fed Alfenas, Dept Farm, BR-37130000 Alfenas, MG, Brazil

[2] Univ Fed Alfenas, Dept Ciencias Exatas, BR-37130000 Alfenas, MG, Brazil

来源：

QUIMICA NOVA | 2010年 / 33卷 / 02期

关键词：

losartan potassium; full factorial design; dissolution; PERFORMANCE LIQUID-CHROMATOGRAPHY; ACTIVE METABOLITE EXP3174; SOLID-PHASE EXTRACTION; MASS-SPECTROMETRY; HUMAN PLASMA; HYDROCHLOROTHIAZIDE; TABLETS; VALIDATION; DEGRADATION; ANTAGONIST;

D O I：

10.1590/S0100-40422010000200026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work describes the development and validation of a dissolution test for 50 mg losartan potassium capsules using HPLC and UV spectrophotometry. A 2(4) full factorial design was carried out to optimize dissolution conditions and potassium phosphate buffer, pH 6.8 as dissolution medium. basket as apparatus at the stirring speed of 50 rpm and time of 30 min were considered adequate. Both dissolution procedure and analytical methods were validated and a statistical analysis showed that there are no significant differences between HPLC and spectrophotometry. Since there is no official monograph, this dissolution test Could be applied for quality control routine.

引用

页码：377 / 383

页数：7

共 36 条

[1] [Anonymous], 1997, Guidance for Industry: Dissolution Testing of Immediate Release Solid Oral Dosage Forms
[2] [Anonymous], 2008, US PHARM
[3] A comparative study of first-derivative spectrophotometry and high-performance liquid chromatography applied to the determination of losartan potassium in tablets
Ansari, M
Kazemipour, M
Khosravi, F
Baradaran, M
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (10) : 1166 - 1170
[4] Simultaneous determination of hydrochlorothiazide and losartan potassium in tablets by high-performance low-pressure chromatography using a multi-syringe burette coupled to a monolithic column
Antonieta Obando, Maria
Estela, Jose Manuel
Cerda, Victor
[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2008, 391 (06) : 2349 - 2356
[5] Multivariate optimization and validation of an analytical methodology by RP-HPLC for the determination of losartan potassium in capsules
Bonfilio, Rudy
Teixeira Tarley, Cesar Ricardo
Pereira, Gislaine Ribeiro
Nunes Salgado, Herida Regina
de Araujo, Magali Benjamim
[J]. TALANTA, 2009, 80 (01) : 236 - 241
[6] Breier AR, 2005, J PHARM PHARM SCI, V8, P289
[7] Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography
Carlucci, G
Palumbo, G
Mazzeo, P
Quaglia, MG
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 23 (01) : 185 - 189
[8] Determination of losartan in human plasma by liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS): Application to bioequivalence study
Choi, Yoonho
Kim, Jin-Ki
Ban, Eunmi
Park, Jeong-Sook
Kim, Chong-Kook
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2008, 31 (17) : 2643 - 2656
[9] Development and validation of dissolution test for captopril in capsules by HPLC
de Cassia, Roberta
Azevedo, Pimentel
Ribeiro, Gislaine Pereira
de Araujo, Magali Benjamin
[J]. REVISTA BRASILEIRA DE CIENCIAS FARMACEUTICAS, 2008, 44 (02): : 261 - 269
[10] Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms
Dressman, JB
Amidon, GL
Reppas, C
Shah, VP
[J]. PHARMACEUTICAL RESEARCH, 1998, 15 (01) : 11 - 22

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