Use of macrophage as a Trojan horse for cancer nanotheranostics

被引：17
作者：
Qi, Yu [1 ,2 ]
Yan, Xu [1 ,2 ]
Xia, Tian [3 ]
Liu, Sijin [1 ,2 ]
机构：
[1] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Univ Calif Los Angeles, Dept Med, Div NanoMed, Los Angeles, CA 90095 USA
来源：
MATERIALS & DESIGN | 2021年 / 198卷
关键词：
Nanomaterials; Macrophages; Drug delivery; Cancer theranostics; Cancer immunology;
D O I：
10.1016/j.matdes.2020.109388
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Nano-based cancer theranostics are often not as effective as expected due to the low accumulation of nanoparticles in tumors, and cell-aided strategies may represent a rescue to improve the efficacy of nanomedicines. Among the strategies, macrophages appear to be an outstanding candidate due to their wide-spread tissue presence and natural ability to take up nanoparticles carrying cargoes, and also the remarkable capability to modulate tumormicroenvironment for enhanced therapeutic efficacy and anti-tumor immunotherapy. However, there are limitations, inconsistencies, and knowledge gaps in the current stage in developing macrophage-mediated nanotherapeutics to realize its fullest potential. Thus, it demands more efforts on understanding the interplays between macrophage and nanomedicine as well as nanomedicines and tumor cells in modulating anti-cancer immunity in the tumor microenvironment. Here, we recapitulate the current progress and knowledge gaps in the macrophage-mediated nano-drug delivery system, and we also shed light on future research directions towards clinical translation. (C) 2020 Published by Elsevier Ltd.
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页数：7
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