A GABAergic nigrotectal pathway for coordination of drinking behavior

被引：61

作者：

Rossi, Mark A. ^{[1
]}

Li, Haofang E. ^{[1
]}

Lu, Dongye ^{[1
]}

Kim, Il Hwan ^{[2
]}

Bartholomew, Ryan A. ^{[1
]}

Gaidis, Erin ^{[1
]}

Barter, Joseph W. ^{[1
]}

Kim, Namsoo ^{[1
]}

Cai, Min Tong ^{[1
]}

Soderling, Scott H. ^{[2
,4
]}

Yin, Henry H. ^{[1
,3
,4
]}

机构：

[1] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA

[2] Duke Univ, Dept Cell Biol, Durham, NC USA

[3] Duke Univ, Ctr Cognit Neurosci, Durham, NC USA

[4] Duke Univ, Dept Neurobiol, Durham, NC USA

来源：

NATURE NEUROSCIENCE | 2016年 / 19卷 / 05期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

NIGRA PARS RETICULATA; SUPERIOR COLLICULUS; SUBSTANTIA-NIGRA; BASAL GANGLIA; LICKING BEHAVIOR; MOTOR CORTEX; DEEP LAYERS; RAT; NEURONS; ORGANIZATION;

D O I：

10.1038/nn.4285

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. These neurons send GABAergic projections to the deep layers of the orofacial region of the lateral tectum (superior colliculus, SC). Many tectal neurons were also time-locked to licking, but their activity was usually in antiphase with that of SNR neurons, suggesting inhibitory nigrotectal projections. We used optogenetics to selectively activate the GABAergic nigrotectal afferents in the deep layers of the SC. Photo-stimulation of the nigrotectal projections transiently inhibited the activity of the lick-related tectal neurons, disrupted their licking-related oscillatory pattern and suppressed self-initiated drinking. These results demonstrate that GABAergic nigrotectal projections have a crucial role in coordinating drinking behavior.

引用

页码：742 / +

页数：9

共 44 条

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