Centrosome aberrations: Cause or consequence of cancer progression?

被引：612
作者：
Nigg, EA [1 ]
机构：
[1] Max Planck Inst Biochem, Dept Cell Biol, D-82152 Martinsried, Germany
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 11期
关键词：
D O I：
10.1038/nrc924
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Many human tumours show centrosome aberrations, indicating an underlying deregulation of centrosome structure, duplication or segregation. Centrosomes organize microtubule arrays throughout the cell cycle, thereby influencing both tissue architecture and the accuracy of chromosome segregation. But what are the origins of centrosomal abnormalities in tumours, and what impact do they have on the generation of invasive, genetically unbalanced cells during cancer progression?.
引用
收藏
页码：815 / 825
页数：11
相关论文
共 110 条
[31]   Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation [J].
Griffin, CS ;
Simpson, PJ ;
Wilson, CR ;
Thacker, J .
NATURE CELL BIOLOGY, 2000, 2 (10) :757-761
[32]  
Gustafson LM, 2000, LARYNGOSCOPE, V110, P1798
[33]   CELL-CYCLE CONTROL AND CANCER [J].
HARTWELL, LH ;
KASTAN, MB .
SCIENCE, 1994, 266 (5192) :1821-1828
[34]   Persistent increase in chromosome instability in lung cancer - Possible indirect involvement of p53 inactivation [J].
Haruki, N ;
Harano, T ;
Masuda, A ;
Kiyono, T ;
Takahashi, T ;
Tatematsu, Y ;
Shimizu, S ;
Mitsudomi, T ;
Konishi, H ;
Osada, H ;
Fujii, Y ;
Takahashi, T .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (04) :1345-1352
[35]   Requirement of a centrosomal activity for cell cycle progression through G1 into S phase [J].
Hinchcliffe, EH ;
Miller, FJ ;
Cham, M ;
Khodjakov, A ;
Sluder, G .
SCIENCE, 2001, 291 (5508) :1547-1550
[36]   It takes two to tango: understanding how centrosome duplication is regulated throughout the cell cycle [J].
Hinchcliffe, EH ;
Sluder, G .
GENES & DEVELOPMENT, 2001, 15 (10) :1167-1181
[37]   Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts [J].
Hinchcliffe, EH ;
Li, C ;
Thompson, EA ;
Maller, JL ;
Sluder, G .
SCIENCE, 1999, 283 (5403) :851-854
[38]  
Hinchcliffe EH, 2001, METHOD CELL BIOL, V67, P269
[39]   Genomic instability in Gadd45a-deficient mice [J].
Hollander, MC ;
Sheikh, MS ;
Bulavin, DV ;
Lundgren, K ;
Augeri-Henmueller, L ;
Shehee, R ;
Molinaro, TA ;
Kim, KE ;
Tolosa, E ;
Ashwell, JD ;
Rosenberg, MP ;
Zhan, QM ;
Fernández-Salguero, PM ;
Morgan, WF ;
Deng, CX ;
Fornace, AJ .
NATURE GENETICS, 1999, 23 (02) :176-184
[40]   Chromosome segregation and cancer: Cutting through the mystery [J].
Jallepalli, PV ;
Lengauer, C .
NATURE REVIEWS CANCER, 2001, 1 (02) :109-117
12345678910