Centrosome aberrations: Cause or consequence of cancer progression?

被引：612
作者：
Nigg, EA [1 ]
机构：
[1] Max Planck Inst Biochem, Dept Cell Biol, D-82152 Martinsried, Germany
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 11期
关键词：
D O I：
10.1038/nrc924
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Many human tumours show centrosome aberrations, indicating an underlying deregulation of centrosome structure, duplication or segregation. Centrosomes organize microtubule arrays throughout the cell cycle, thereby influencing both tissue architecture and the accuracy of chromosome segregation. But what are the origins of centrosomal abnormalities in tumours, and what impact do they have on the generation of invasive, genetically unbalanced cells during cancer progression?.
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页码：815 / 825
页数：11
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