β cell aging and age-related diabetes

被引：4

作者：

Zhu, Min ^{[1
]}

Liu, Xiaohong ^{[1
]}

Liu, Wen ^{[1
]}

Lu, Yanrong ^{[1
]}

Cheng, Jingqiu ^{[1
,2
]}

Chen, Younan ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, Regenerat Med Res Ctr, Key Lab Transplant Engn & Immunol,NHFPC, Chengdu, Peoples R China

[2] Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Inst Syst Genet, Chengdu, Peoples R China

来源：

AGING-US | 2021年 / 13卷 / 05期

基金：

中国国家自然科学基金;

关键词：

aging; type 2 diabetes (T2D); age-related diabetes; beta cell function; beta cell senescence; ISLET AMYLOID POLYPEPTIDE; CHRONIC OXIDATIVE STRESS; INSULIN-SECRETION; GLUCOSE TOXICITY; SENESCENCE; APOPTOSIS; MECHANISM; DEDIFFERENTIATION; DYSFUNCTION; PANCREAS;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Type 2 diabetes is characterized by insulin resistance and loss of beta cell mass and function. Aging is considered as a major risk factor for development of type 2 diabetes. However, the roles of pancreatic beta cell senescence and systemic aging in the pathogenesis of type 2 diabetes in elderly people remain poorly understood. In this review, we aimed to discuss the current findings and viewpoints focusing on beta cell aging and the development of type 2 diabetes.

引用

页码：7691 / 7706

页数：16

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