Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I

被引：42

作者：

Shen, Qihui ^{[1
]}

Liu, Man ^{[3
]}

Lu, Yang ^{[1
]}

Zhang, Dawei ^{[1
]}

Cheng, Zhenyu ^{[1
]}

Liu, Yan ^{[1
]}

Gao, Huajing ^{[2
]}

Jin, Zhaohui ^{[2
]}

机构：

[1] Jilin Inst Chem Technol, Dept Chem & Pharmaceut Engn, Jilin 132022, Jilin, Peoples R China

[2] Jilin Inst Chem Technol, Dept Petrochem Technol, Jilin 132022, Jilin, Peoples R China

[3] Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Coll Chem, Changchun 130012, Jilin, Peoples R China

来源：

ACS OMEGA | 2019年 / 4卷 / 07期

关键词：

IMMUNOASSAY; DIALDEHYDE; COMPOSITE; ANTIBODY; ACID;

D O I：

10.1021/acsomega.9b01152

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A label-free electrochemical immunosensor for cardiac troponin I was prepared by using a helical carbon nanotube-supported aldehyde-functionalized ionic liquid. Because of the good conductivity of ionic liquid and helical carbon nanotubes, high sensitivity of the immunosensor was obtained. Functionalized ionic liquid provided binding sites for antibody, which simplified the process of sensor construction. Cardiac troponin I was detected by this immunosensor with a linear range of 0.05-30 ng/mL and a detection limit of 0.03 ng/mL. The electrochemical immunosensor had satisfactory reproducibility, high sensitivity, and acceptable specificity.

引用

页码：11888 / 11892

页数：5

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