Effect of masseter muscle mass on the rate of experimental tooth movement in rats

被引：3

作者：

Arizono-Shimada, Keira ^{[1
]}

Hotokezaka, Hitoshi ^{[1
]}

Morita, Yukiko ^{[1
]}

Ino-Kondo, Airi ^{[1
]}

Ueda-Ichinose, Yuika ^{[1
]}

Nashiro, Yukako ^{[1
]}

Hotokezaka, Yuka ^{[2
]}

Yoshimi, Keiko ^{[3
]}

Kiliaridis, Stavros ^{[4
,5
]}

Yoshida, Noriaki ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Orthodont & Dentofacial Orthoped, 1-7-1 Sakamoto, Nagasaki 8528588, Japan

[2] Nagasaki Univ, Dept Clin Oral Oncol, Grad Sch Biomed Sci, Nagasaki, Japan

[3] Yoshimi Skin Clin, Nagasaki, Japan

[4] Univ Geneva, Univ Clin Dent Med, Div Orthodont, Geneva, Switzerland

[5] Univ Bern, Dept Orthodont, Dentofacial Orthoped, Bern, Switzerland

来源：

JOURNAL OF ORAL REHABILITATION | 2022年 / 49卷 / 10期

关键词：

bone morphometry; botulinum neurotoxin type A; masseter muscle; masticatory muscle; micro-computed tomography; orthodontic tooth movement; MOTOR COORDINATION; BITE FORCE; APPLIANCE; THICKNESS; MAGNITUDE; FIBER;

D O I：

10.1111/joor.13357

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Background Previous clinical observational studies have suggested that orthodontic tooth movement (OTM) is related, at least partly, to the mass and/or capabilities of the masticatory muscles. Objectives Our study aimed to examine the influence of masticatory muscle mass on the OTM in an animal experimental model in which the masseter muscle was modulated by botulinum neurotoxin type A (BTX) injection. Methods Eighteen Wistar rats were equally divided into two groups: BTX injection and control. BTX was injected bilaterally into the masseter muscles. Three days after the injection, the maxillary left first molars were orthodontically moved for 14 days. At the end of the experiment, micro-computed tomography was performed to evaluate the rate of OTM and bone morphometry. The masseter muscles were weighed and prepared for histological analyses. Results The masseter muscle mass in the BTX group was less than that in the control group, and histological findings showed atrophy of muscle fibres. The rate of OTM was significantly higher in the BTX group than in the control group. Furthermore, a negative correlation was detected between masseter muscle mass and OTM in the BTX group. Bone morphometry showed no difference between the control and BTX groups. Conclusion Decreased masseter muscle mass was found to be closely related to an increase in the rate of OTM in rats using BTX injection to modify the masseter muscle mass. Masseter muscle mass could be a predictive factor for OTM in rats injected with BTX.

引用

页码：1012 / 1019

页数：8