Chemical Composition, Antioxidant and Cytotoxic Activities of Roots and Fruits of Berberis libanotica

被引：8
作者：
El Hosry, Leina [1 ]
Boyer, Laurent [1 ]
Garayev, Elnur E. [1 ]
Mabrouki, Fathi [1 ]
Bun, Sok-Siya [1 ]
Debrauwer, Laurent [2 ]
Auezova, Lizette [3 ]
Cheble, Edmond [4 ]
Elias, Riad [1 ]
机构：
[1] Aix Marseille Univ, Fac Pharm, Lab Pharmacognosie & Ethnopharmacol, UMR MD3, 27 Blvd Jean Moulin,CS30064, F-13385 Marseille 5, France
[2] INRA, UMR Toxalim 1331, 180 Chemin Tournefeuille, F-31027 Toulouse 3, France
[3] Lebanese Univ, Fac Sci 2, Dept Chem, POB 90656, Fanar, Jdaidet El Matn, Lebanon
[4] Lebanese Univ, Fac Pharm, Hadath Campus, Beirut, Lebanon
来源：
NATURAL PRODUCT COMMUNICATIONS | 2016年 / 11卷 / 05期
关键词：
Berberis libanotica; Phenolic compounds; Alkaloids; Cytotoxicity; Antioxidant; MICROPHYLLA FRUITS;
D O I：
10.1177/1934578X1601100523
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fourteen compounds belonging to different chemical classes were characterized in the roots and fruits extracts from Berberis libanotica, using the same HPLC-DAD-MS method. Thirteen were reported, for the first time, from the fruits whereas the roots contained mostly alkaloids of which 3 out of 5 are reported for the first time. Their structures were established on the basis of MS data as gallic acid (1), chlorogenic acid (2), delphinidin (3), oxyacanthine (4), rutin (5), hyperoside (6), berbamine (7), isoquercitrin (8), quercitrin (9), jatrorrhizine (10), palmatine (11), berberine (12), quercetin (13) and luteolin (14). Extracts containing compounds 4 and 7 showed significant cytotoxicity against the HT29 cell line with an IC50 of 12.2-26.1 mu g/mL. Fruits extracts, due mostly to compounds 1 and 2, showed potent antioxidant activities with an EC50 of 0.0025-0.019 mg/mL.
引用
收藏
页码：645 / 648
页数：4
相关论文
共 50 条
  • [41] Chemical Constituents of Thesium chinense Turcz and Their In Vitro Antioxidant, Anti-Inflammatory and Cytotoxic Activities
    Liu, Zhen-Zhen
    Ma, Jun-Cheng
    Deng, Peng
    Ren, Fu-Cai
    Li, Ning
    MOLECULES, 2023, 28 (06):
  • [42] Chemical composition and antioxidant, cytotoxic, and insecticidal potential of Valeriana alliariifolia in Turkey
    Sen-Utsukarci, Burcu
    Taskin, Turgut
    Goger, Fatih
    Tabanca, Nurhayat
    Estep, Alden S.
    Kessler, Sonja M.
    Akbal-Dagistan, Ozlem
    Bardakci, Hilal
    Kurkcuoglu, Mine
    Becnel, James
    Kiemer, Alexandra
    Mat, Afife
    ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY, 2019, 70 (03): : 207 - 218
  • [43] Methanolic extracts of Withania somnifera leaves, fruits and roots possess antioxidant properties and antibacterial activities
    Alam, Nadia
    Hossain, Monzur
    Mottalib, Md Abdul
    Sulaiman, Siti Amrah
    Gan, Siew Hua
    Khalil, Md Ibrahim
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, 12
  • [44] Phytochemical profile of Tunisian Pistacia lentiscus fruits oil: Antioxidant, antiplatelet, and cytotoxic activities assessment
    Ben Ameur, Raoudha
    Hadjkacem, Basma
    Ayadi, Mohamed
    Ikram, Ben Amor
    Feki, Amira
    Gargouri, Jalel
    Gargouri, Ali
    Allouche, Noureddine
    EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2024,
  • [45] Chemical Composition and Antibacterial, Antioxidant, and Cytotoxic Activities of Essential Oils from Leaves and Stems of Aeschynomene indica L.
    Feng, Linjie
    Xu, Fan
    Qiu, Shu
    Sun, Chengqi
    Lai, Pengxiang
    MOLECULES, 2024, 29 (15):
  • [46] Methanolic extracts of Withania somnifera leaves, fruits and roots possess antioxidant properties and antibacterial activities
    Nadia Alam
    Monzur Hossain
    Md Abdul Mottalib
    Siti Amrah Sulaiman
    Siew Hua Gan
    Md Ibrahim Khalil
    BMC Complementary and Alternative Medicine, 12
  • [47] Phytochemical composition and antidiabetic, anti-obesity, antioxidant, and cytotoxic activities of Carthamus tinctorius seed oil
    Jaradat, Nidal
    Hawash, Mohammed
    Ghanim, Mustafa
    Alqub, Malik
    Rabayaa, Maha
    Dwikat, Majdi
    Issa, Linda
    Hussein, Fatima
    Asadi, Lana
    Yassin, Larin
    Rabee, Heba
    Gamhur, Asil
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [48] Chemical Composition and Antioxidant Activities of the Essential oil of Olax acuminata
    Chetia, Bolin
    Phukan, Alakesh
    JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2014, 17 (04) : 696 - 701
  • [49] Chemical Composition Analysis, Antioxidant, and Antibacterial Activities of Eggplant Leaves
    Bouhajeb, Rim
    Selmi, Salima
    Nakbi, Amel
    Jlassi, Ibrahim
    Montevecchi, Giuseppe
    Flamini, Guido
    Zarrad, Imen
    Dabbou, Samia
    CHEMISTRY & BIODIVERSITY, 2020, 17 (12)
  • [50] Flavonoids composition, antioxidant, anticholinesterase, and cytotoxic activities of flowers extract of Senna cearensis Afr. Fern
    Franca, Maria G. A.
    Oliveira, Ana Paula S.
    Lima, Daniele R.
    Oliveira, Fatima C. E.
    Paiva, Cristiane F.
    Pessoa, Claudia O.
    Trevisan, Maria T. S.
    Silva, Maria G. V.
    NATURAL PRODUCT RESEARCH, 2023, 37 (11) : 1892 - 1896
12345