Chemical Composition, Antioxidant and Cytotoxic Activities of Roots and Fruits of Berberis libanotica

被引：8
作者：
El Hosry, Leina [1 ]
Boyer, Laurent [1 ]
Garayev, Elnur E. [1 ]
Mabrouki, Fathi [1 ]
Bun, Sok-Siya [1 ]
Debrauwer, Laurent [2 ]
Auezova, Lizette [3 ]
Cheble, Edmond [4 ]
Elias, Riad [1 ]
机构：
[1] Aix Marseille Univ, Fac Pharm, Lab Pharmacognosie & Ethnopharmacol, UMR MD3, 27 Blvd Jean Moulin,CS30064, F-13385 Marseille 5, France
[2] INRA, UMR Toxalim 1331, 180 Chemin Tournefeuille, F-31027 Toulouse 3, France
[3] Lebanese Univ, Fac Sci 2, Dept Chem, POB 90656, Fanar, Jdaidet El Matn, Lebanon
[4] Lebanese Univ, Fac Pharm, Hadath Campus, Beirut, Lebanon
来源：
NATURAL PRODUCT COMMUNICATIONS | 2016年 / 11卷 / 05期
关键词：
Berberis libanotica; Phenolic compounds; Alkaloids; Cytotoxicity; Antioxidant; MICROPHYLLA FRUITS;
D O I：
10.1177/1934578X1601100523
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fourteen compounds belonging to different chemical classes were characterized in the roots and fruits extracts from Berberis libanotica, using the same HPLC-DAD-MS method. Thirteen were reported, for the first time, from the fruits whereas the roots contained mostly alkaloids of which 3 out of 5 are reported for the first time. Their structures were established on the basis of MS data as gallic acid (1), chlorogenic acid (2), delphinidin (3), oxyacanthine (4), rutin (5), hyperoside (6), berbamine (7), isoquercitrin (8), quercitrin (9), jatrorrhizine (10), palmatine (11), berberine (12), quercetin (13) and luteolin (14). Extracts containing compounds 4 and 7 showed significant cytotoxicity against the HT29 cell line with an IC50 of 12.2-26.1 mu g/mL. Fruits extracts, due mostly to compounds 1 and 2, showed potent antioxidant activities with an EC50 of 0.0025-0.019 mg/mL.
引用
收藏
页码：645 / 648
页数：4
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