Asymmetric intercalation of N1-(acridin-9-ylcarbonyl)spermine at homopurine sites of duplex DNA

被引：25
作者：
Blagbrough, IS
Taylor, S
Carpenter, ML
Novoselskiy, V
Shamma, T
Haworth, IS
机构：
[1] Univ So Calif, Dept Pharmaceut Sci, Los Angeles, CA 90033 USA
[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
[3] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England
来源：
CHEMICAL COMMUNICATIONS | 1998年 / 08期
关键词：
D O I：
10.1039/a709193a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N-1-(Acridin-9-ylcarbonyl)spermine binds at 5'-pu-p-pu..5'-py-p-py sites of DNA with the acridine moiety asymmetrically intercalated, stacked between the two purine bases; the spermine moiety interacts with the homopyrimidine phosphodiester backbone of the intercalation site and protects against DNase I cleavage of this backbone, but does not protect against cleavage of the homopurine backbone at the same intercalation site.
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页码：929 / 930
页数：2
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