Synthesis, characterization, and biological applications of pyrazole moiety bearing osmium(IV) complexes

被引：2
|
作者：
Pursuwani, Bharat H. [1 ]
Bhatt, Bhupesh S. [1 ]
Raval, Dilip B. [2 ]
Thakkar, Vasudev R. [2 ]
Sharma, Jyoti [3 ]
Pathak, Chandramani [3 ]
Patel, Mohan N. [1 ]
机构：
[1] Sardar Patel Univ, Chem, Vallabh Vidyanagar 388120, Gujarat, India
[2] Sardar Patel Univ, Biosci, Vallabh Vidyanagar, Gujarat, India
[3] Amity Univ, Amity Inst Biotechnol, Gurgaon, Haryana, India
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2021年 / 40卷 / 06期
关键词：
Pyrazole nucleus; absorption titration; docking; Os(IV) complexes; DNA-BINDING; COPPER(II) COMPLEXES; METAL(II) COMPLEXES; ANTICANCER ACTIVITY; CRYSTAL-STRUCTURE; RUTHENIUM(II); ANTIOXIDANT; DERIVATIVES; LIGANDS;
D O I：
10.1080/15257770.2021.1921795
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Osmium (IV) complexes with pyrazole nucleus containing ligands were synthesized. Os(IV) compounds were characterized using ESI-MS, ICP-OES, IR spectroscopy, electronic spectroscopy, conductance, and magnetic measurements. Whereas, ligands were characterized by heteronuclear spectroscopy, (H-1 and C-13), IR spectroscopy, and elemental analysis. All the compounds were tested for their potential to interact with HS-DNA by absorption titration, fluorescence spectroscopy, viscosity measurement, and docking study. The quenching constant and Stern Volmer constant values were calculated using fluorescence study. The synthesized compounds were studied for in-vitro bacteriostatic and cytotoxic activities. The cancer cell line studies of all the synthesized complexes were carried out on human lung cancer cells (A549). Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1921795 .
引用
收藏
页码：593 / 618
页数：26
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