Preparation of 5-diaminomethylenebarbiturates by barbituric acid addition to carbodiimides

被引：22

作者：

Jursic, BS ^{[1
]}

Douelle, F ^{[1
]}

Stevens, ED ^{[1
]}

机构：

[1] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

来源：

TETRAHEDRON | 2003年 / 59卷 / 19期

关键词：

barbituric acid; 5-diaminomethylenebarbiturates; immuno-modulating agents;

D O I：

10.1016/S0040-4020(03)00489-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Through NMR spectroscopic monitoring of barbituric acid addition to carbodiimide, a general synthetic procedure for the preparation of 5-diaminomethylenebarbiturates (DABA) was developed. This procedure is very simple and applicable to the preparation of large quantities of DABA derivatives. Through an X-ray structural study of one of the DABA derivatives, it was established that these compounds have an ylide-type structure with strong charge separation within the molecule. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3427 / 3432

页数：6

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