Acetate as a potential feedstock for the production of value-added chemicals: Metabolism and applications

被引:91
作者
Kim, Yeonhee [1 ]
Lama, Suman [1 ]
Agrawal, Deepti [3 ]
Kumar, Vinod [2 ]
Park, Sunghoon [1 ]
机构
[1] UNIST, Sch Energy & Chem Engn, 50 UNIST Gil, Ulsan 44919, South Korea
[2] Cranfield Univ, Sch Water Energy & Environm, Ctr Climate & Environm Protect, Cranfield MK43 0AL, Beds, England
[3] CSIR Indian Inst Petr, Mat Resource Efficiency Div, Biochem & Biotechnol Area, Dehra Dun 248005, Uttarakhand, India
基金
新加坡国家研究基金会;
关键词
Acetate; Value-added chemicals; Metabolism; Regulations; Tolerance; ACETIC-ACID RESISTANCE; COENZYME-A SYNTHETASE; ESCHERICHIA-COLI STRAINS; PQQ-DEPENDENT ADH; ISOCITRATE LYASE; COA SYNTHETASE; CORYNEBACTERIUM-GLUTAMICUM; SACCHAROMYCES-CEREVISIAE; GENE-EXPRESSION; ADAPTIVE EVOLUTION;
D O I
10.1016/j.biotechadv.2021.107736
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Acetate is regarded as a promising carbon feedstock in biological production owing to its possible derivation from C1 gases such as CO, CO2 and methane. To best use of acetate, comprehensive understanding of acetate metabolisms from genes and enzymes to pathways and regulations is needed. This review aims to provide an overview on the potential of acetate as carbon feedstock for industrial biotechnology. Biochemical, microbial and biotechnological aspects of acetate metabolism are described. Especially, the current state-of-the art in the production of value-added chemicals from acetate is summarized. Challenges and future perspectives are also provided.
引用
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页数:25
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