Active and passive smoking and breast cancer risk in middle-aged Japanese women

被引:59
作者
Hanaoka, T [1 ]
Yamamoto, S
Sobue, T
Sasaki, S
Tsugane, S
机构
[1] Natl Canc Ctr, Epidemiol & Prevent Div, Res Ctr Canc Prevent & Screening, Tokyo 1040045, Japan
[2] Natl Canc Ctr, Res Inst, Stat & Canc Control Div, Tokyo 1040045, Japan
[3] Natl Inst Hlth & Nutr, Tokyo 162, Japan
关键词
breast neoplasms; smoking passive smoking; cohort study;
D O I
10.1002/ijc.20709
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To examine the hypothesis that tobacco smoke is associated with the risk of female breast cancer, we estimated the relative risks of active and passive smoke in middle-aged Japanese women in a population-based prospective study. The cohort consisted of residents in 4 public health center areas, aged 40 to 59 years. A self-administered questionnaire survey was conducted in 1990. This analysis included 21,805 subjects, 180 of whom had developed breast cancer by December 31, 1999. When the reference was defined as never-active smokers without passive smoking, adjusted relative risks (RRs) were 1.9 (95% confidence interval [CI] = 1.0-3.6) in current active smokers, 1.2 (95% CI = 0.4-4.0) in ex-active smokers and 1.2 (95% CI = 0.8-1.6) in never-active smokers with passive smoking. The elevated risk for ever-smokers was clearly observed in premenopausal women at baseline (RR = 3.9, 95% CI = 1.5-9.9) but not in postmenopausal women (RR = 1.1, 95% CI = 0.5-2.5). In never-active smokers, the adjusted RR for passive smoking, residential or occupational/public tobacco smoke exposure was 1.1 (95% CI = 0.8-1.6). In premenopausal women. passive smoking increased the risk (RR = 2.6; 95% CI = 1.3-5.2) but not in postmenopausal women (RR = 0.7; 95% CI = 0.4-1.0). We conclude that tobacco smoking increases the risk of female breast cancer in premenopausal women. (C) 2004 Wiley-Liss. Inc.
引用
收藏
页码:317 / 322
页数:6
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