The Molecular Landscape of Noninvasive Follicular Thyroid Neoplasm With Papillary-like Nuclear Features (NIFTP): A Literature Review

被引:28
作者
Basolo, Fulvio [1 ]
Macerola, Elisabetta [1 ]
Ugolini, Clara [2 ]
Poller, David N. [3 ]
Baloch, Zubair [4 ]
机构
[1] Univ Pisa, Dept Surg Med Mol Pathol & Crit Area, Pisa, Italy
[2] Univ Hosp Pisa, Div 3, Unit Pathol Anat, Pisa, Italy
[3] Univ Portsmouth, Queen Alexandra Hosp, Dept Pathol, Portsmouth, Hants, England
[4] Hosp Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, 3400 Spruce St, Philadelphia, PA 19104 USA
关键词
thyroid; papillary; follicular; NIFTP; molecular; diagnosis; YOUNG INVESTIGATOR CHALLENGE; GENE-EXPRESSION CLASSIFIER; ASSOCIATION GUIDELINES; BETHESDA SYSTEM; TASK-FORCE; VARIANT; CARCINOMA; NODULES; CANCER; BRAF;
D O I
10.1097/PAP.0000000000000163
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The encapsulated and noninvasive follicular variant of papillary thyroid carcinoma has been recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These tumors demonstrate indolent behavior. This change in nomenclature will have great clinical impact by avoiding overtreatment of patients with NIFTP lesions who in the past were diagnosed with thyroid carcinoma and typically received completion thyroidectomy followed by radioactive iodine ablation. The pathologic diagnosis of NIFTP requires surgical removal of the thyroid lesion or the lobe harboring it, and thorough sampling of the complete interface between the tumor capsule and the thyroid parenchyma, to exclude foci of invasion. From a cytologic point of view, the unequivocal differential diagnosis between NIFTP and infiltrative follicular variant of papillary thyroid carcinoma in fine-needle aspiration is close to impossible based on cellular and architectural features. Therefore, use of adjunct molecular testing on fine-needle aspiration specimens may be essential for the preoperative diagnosis of low-risk tumors such as NIFTP for appropriate patient management. This review discusses and summarizes the existing known literature on molecular characteristics of NIFTP tumors, so far reported, including cases retrospectively classified or prospectively diagnosed as NIFTP. Brief reference is also made to new and promising approaches applicable to the diagnosis of this tumor.
引用
收藏
页码:252 / 258
页数:7
相关论文
共 45 条
[1]   Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAFK601E Mutation [J].
Afkhami, Michelle ;
Karunamurthy, Arivarasan ;
Chiosea, Simion ;
Nikiforova, Marina N. ;
Seethala, Raja ;
Nikiforov, Yuri E. ;
Coyne, Christopher .
THYROID, 2016, 26 (02) :242-247
[2]   Integrated Genomic Characterization of Papillary Thyroid Carcinoma [J].
Agrawal, Nishant ;
Akbani, Rehan ;
Aksoy, B. Arman ;
Ally, Adrian ;
Arachchi, Harindra ;
Asa, Sylvia L. ;
Auman, J. Todd ;
Balasundaram, Miruna ;
Balu, Saianand ;
Baylin, Stephen B. ;
Behera, Madhusmita ;
Bernard, Brady ;
Beroukhim, Rameen ;
Bishop, Justin A. ;
Black, Aaron D. ;
Bodenheimer, Tom ;
Boice, Lori ;
Bootwalla, Moiz S. ;
Bowen, Jay ;
Bowlby, Reanne ;
Bristow, Christopher A. ;
Brookens, Robin ;
Brooks, Denise ;
Bryant, Robert ;
Buda, Elizabeth ;
Butterfield, Yaron S. N. ;
Carling, Tobias ;
Carlsen, Rebecca ;
Carter, Scott L. ;
Carty, Sally E. ;
Chan, Timothy A. ;
Chen, Amy Y. ;
Cherniack, Andrew D. ;
Cheung, Dorothy ;
Chin, Lynda ;
Cho, Juok ;
Chu, Andy ;
Chuah, Eric ;
Cibulskis, Kristian ;
Ciriello, Giovanni ;
Clarke, Amanda ;
Clayman, Gary L. ;
Cope, Leslie ;
Copland, John A. ;
Covington, Kyle ;
Danilova, Ludmila ;
Davidsen, Tanja ;
Demchok, John A. ;
DiCara, Daniel ;
Dhalla, Noreen .
CELL, 2014, 159 (03) :676-690
[3]   Encapsulated follicular variant of papillary thyroid carcinoma/noninvasive follicular thyroid neoplasm with papillary-like nuclear features with Spindle Cell Metaplasia: Case report and review of literature [J].
Al Rasheed, Mohamed Rizwan Haroon ;
Acosta, Andres ;
Tarjan, Gabor .
PATHOLOGY RESEARCH AND PRACTICE, 2017, 213 (04) :416-421
[4]   Qualifiers of Atypia in the Cytologic Diagnosis of Thyroid Nodules Are Associated With Different Afirma Gene Expression Classifier Results and Clinical Outcomes [J].
Baca, Sylvan C. ;
Wong, Kristine S. ;
Strickland, Kyle C. ;
Heller, Howard T. ;
Kim, Matthew I. ;
Barletta, Justine A. ;
Cibas, Edmund S. ;
Krane, Jeffrey F. ;
Marqusee, Ellen ;
Angell, Trevor E. .
CANCER CYTOPATHOLOGY, 2017, 125 (05) :313-322
[5]   Young Investigator Challenge: The Morphologic Analysis of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features on Liquid-Based Cytology: Some Insights Into Their Identification [J].
Bizzarro, Tommaso ;
Martini, Maurizio ;
Capodimonti, Sara ;
Straccia, Patrizia ;
Lombardi, Celestino Pio ;
Pontecorvi, Alfredo ;
Larocca, Luigi Maria ;
Rossi, Esther Diana .
CANCER CYTOPATHOLOGY, 2016, 124 (10) :699-710
[6]  
Borrelli N, 2017, MODERN PATHOL, V30, P39, DOI [10.1038/nnodpathol.2016.157, 10.1038/modpathol.2016.157]
[7]   New Concept of the Encapsulated Follicular Variant of Papillary Thyroid Carcinoma and Its Impact on the Bethesda System for Reporting Thyroid Cytopathology: A Single-Institute Experience [J].
Canberk, Sule ;
Gunes, Pembegul ;
Onenerk, Mine ;
Erkan, Murat ;
Kilinc, Emine ;
Gursan, Nilufer Kocak ;
Kilicoglu, Gamze Z. .
ACTA CYTOLOGICA, 2016, 60 (03) :198-204
[8]   FOLLICULAR VARIANT OF THYROID PAPILLARY CARCINOMA - CLINICOPATHOLOGIC STUDY OF 6 CASES [J].
CHEN, KTK ;
ROSAI, J .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1977, 1 (02) :123-130
[9]   Identification of new biomarkers for human papillary thyroid carcinoma employing NanoString analysis [J].
Chitikova, Zhanna ;
Pusztaszeri, Marc ;
Makhlouf, Anne-Marie ;
Berczy, Margaret ;
Delucinge-Vivier, Celine ;
Triponez, Frederic ;
Meyer, Patrick ;
Philippe, Jacques ;
Dibner, Charna .
ONCOTARGET, 2015, 6 (13) :10978-10993
[10]   Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features [J].
Cho, Uiju ;
Mete, Ozgur ;
Kim, Min-Hee ;
Bae, Ja Seong ;
Jung, Chan Kwon .
MODERN PATHOLOGY, 2017, 30 (06) :810-825