Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes with N,O-Chelating Pyrazolone-Based β-Ketoamine Ligands

被引：51

作者：

Pettinari, Riccardo ^{[1
]}

Marchetti, Fabio ^{[2
]}

Pettinari, Claudio ^{[1
]}

Petrini, Agnese ^{[1
]}

Scopelliti, Rosario ^{[3
]}

Clavel, Catherine M. ^{[3
]}

Dyson, Paul J. ^{[3
]}

机构：

[1] Univ Camerino, Sch Pharm, I-62032 Camerino, Macerata, Italy

[2] Univ Camerino, Sch Sci & Technol, I-62032 Camerino, Macerata, Italy

[3] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

INORGANIC CHEMISTRY | 2014年 / 53卷 / 24期

基金：

瑞士国家科学基金会;

关键词：

ANTICANCER COMPLEXES; ANTITUMOR COMPOUNDS; CHEMISTRY; DRUG; COORDINATION; AGENTS;

D O I：

10.1021/ic502274b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Novel ruthenium half-sandwich complexes containing (N,O)-bound pyrazolone-based beta-ketoamine ligands have been prepared, and the solid-state structures of one ligand and five complexes have been determined by single-crystal X-ray diffraction. Some of the complexes display moderate cytotoxicity toward the human ovarian cancer cell lines A2780 and A2780cisR, the latter line having acquired resistance to cisplatin.

引用

页码：13105 / 13111

页数：7

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