Development and biological assessment of fully water-soluble helical aromatic amide foldamers

被引：92
作者：
Gillies, Elizabeth R.
Deiss, Frederique
Staedel, Cathy
Schmitter, Jean-Marie
Huc, Ivan
机构：
[1] Univ Bordeaux 1, CNRS, UMR5248, Inst European Chim & Biol, F-33607 Pessac, France
[2] Univ Bordeaux 2, INSERM, U869, F-33076 Bordeaux, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 22期
关键词：
drug delivery; helical structures; medicinal chemistry; peptidomimetics;
D O I：
10.1002/anie.200700301
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Abiotic but bioactive: Folding aromatic amide oligomers possessing helical structures very different from those of α-peptides, β-peptides, or peptoids nevertheless show comparable abilities to penetrate into cells, as well as low toxicity and complete resistance to protease degradation. TFA - = trifluoroacetate. (Chemical Equation Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4081 / 4084
页数：4
相关论文
共 70 条
  • [11] The design and evaluation of heparin-binding foldamers
    Choi, S
    Clements, DJ
    Pophristic, V
    Ivanov, I
    Vemparala, S
    Bennett, JS
    Klein, ML
    Winkler, JD
    DeGrado, WE
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (41) : 6685 - 6689
  • [12] Choi S., 2005, ANGEW CHEM, V117, P6843
  • [13] Delsuc N., 2007, ANGEW CHEM, V119, P218
  • [14] Proteomorphous objects from abiotic backbones
    Delsuc, Nicolas
    Leger, Jean-Michel
    Massip, Stephane
    Huc, Ivan
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (1-2) : 214 - 217
  • [15] Solution structure of quinoline- and pyridine-derived oligoamide foldamers
    Dolain, C
    Grélard, A
    Laguerre, M
    Jiang, H
    Maurizot, V
    Huc, I
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (21) : 6135 - 6144
  • [16] Probing helix propensity of monomers within a helical oligomer
    Dolain, C
    Léger, JM
    Delsuc, N
    Gornitzka, H
    Huc, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (45) : 16146 - 16151
  • [17] Ernst J. T., 2003, ANGEW CHEM, V115, P553
  • [18] Design and application of an α-helix-mimetic scaffold based on an oligoamide-foldamer strategy:: Antagonism of the bak BH3/Bcl-xL complex
    Ernst, JT
    Becerril, J
    Park, HS
    Yin, H
    Hamilton, AD
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (05) : 535 - +
  • [19] Cell penetrating agents based on a polyproline helix scaffold
    Fillon, YA
    Anderson, JP
    Chmielewski, J
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (33) : 11798 - 11803
  • [20] Frackenpohl J, 2001, CHEMBIOCHEM, V2, P445, DOI 10.1002/1439-7633(20010601)2:6<445::AID-CBIC445>3.0.CO
1234567