Development and biological assessment of fully water-soluble helical aromatic amide foldamers

被引：92
作者：
Gillies, Elizabeth R.
Deiss, Frederique
Staedel, Cathy
Schmitter, Jean-Marie
Huc, Ivan
机构：
[1] Univ Bordeaux 1, CNRS, UMR5248, Inst European Chim & Biol, F-33607 Pessac, France
[2] Univ Bordeaux 2, INSERM, U869, F-33076 Bordeaux, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 22期
关键词：
drug delivery; helical structures; medicinal chemistry; peptidomimetics;
D O I：
10.1002/anie.200700301
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Abiotic but bioactive: Folding aromatic amide oligomers possessing helical structures very different from those of α-peptides, β-peptides, or peptoids nevertheless show comparable abilities to penetrate into cells, as well as low toxicity and complete resistance to protease degradation. TFA - = trifluoroacetate. (Chemical Equation Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4081 / 4084
页数：4
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