Role of Feline Immunodeficiency Virus in Lymphomagenesis-Going Alone or Colluding?

被引：14

作者：

Kaye, Sarah ^{[1
]}

Wang, Wenqi ^{[2
]}

Miller, Craig ^{[3
]}

McLuckie, Alicia ^{[4
]}

Beatty, Julia A. ^{[4
]}

Grant, Chris K. ^{[5
]}

VandeWoude, Sue ^{[3
,6
]}

Bielefeldt-Ohmann, Helle ^{[2
,7
,8
]}

机构：

[1] Anim Welf League Qld Inc, Gold Coast, Qld, Australia

[2] Univ Queensland Gatton, Sch Vet Sci, Gatton, Qld, Australia

[3] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

[4] Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia

[5] Custom Monoclonals Int Corp, West Sacramento, CA USA

[6] Colorado State Univ, Coll Vet & Biomed Sci, Ft Collins, CO 80523 USA

[7] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld, Australia

[8] Univ Queensland, Australian Infect Dis Res Ctr, St Lucia, Qld, Australia

来源：

ILAR JOURNAL | 2016年 / 57卷 / 01期

关键词：

cat; feline immunodeficiency virus (FIV); feline leukemia virus (FeLV); gamma-herpesvirus; human immunodeficiency virus (HIV) model; lymphoma; lymphomagenesis; SARCOMA-ASSOCIATED HERPESVIRUS; EPSTEIN-BARR-VIRUS; RHESUS MACAQUE RHADINOVIRUS; DOMESTIC CATS; GAMMA-HERPESVIRUSES; FIV INFECTION; HIV-INFECTION; LYMPHOPROLIFERATIVE DISORDER; PLACENTAL IMMUNOPATHOLOGY; (FIV)-ASSOCIATED LYMPHOMA;

D O I：

10.1093/ilar/ilv047

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Feline immunodeficiency virus (FIV) is a naturally occurring lentivirus of domestic and nondomestic feline species. Infection in domestic cats leads to immune dysfunction via mechanisms similar to those caused by human immunodeficiency virus (HIV) and, as such, is a valuable natural animal model for acquired immunodeficiency syndrome (AIDS) in humans. An association between FIV and an increased incidence of neoplasia has long been recognized, with frequencies of up to 20% in FIV-positive cats recorded in some studies. This is similar to the rate of neoplasia seen in HIV-positive individuals, and in both species neoplasia typically requires several years to arise. The most frequently reported type of neoplasia associated with FIV infection is lymphoma. Here we review the possible mechanisms involved in FIV lymphomagenesis, including the possible involvement of coinfections, notably those with gamma-herpesviruses.

引用

页码：24 / 33

页数：10

共 104 条

[1] REGIONAL DISTRIBUTION OF LESIONS IN THE CENTRAL-NERVOUS-SYSTEM OF CATS INFECTED WITH FELINE IMMUNODEFICIENCY VIRUS [J].