Gadolinium deposition in the brain: summary of evidence and recommendations

被引：585

作者：

Gulani, Vikas ^{[1
,2
,3
,4
]}

Calamante, Fernando ^{[5
,6
]}

Shellock, Frank G. ^{[7
,8
,9
]}

Kanal, Emanuel ^{[10
]}

Reeder, Scott B. ^{[11
,12
,13
,14
,15
]}

机构：

[1] Case Western Reserve Univ, Case Comprehens Canc Ctr, Dept Radiol, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Case Comprehens Canc Ctr, Dept Urol, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Case Comprehens Canc Ctr, Dept Biomed Engn, Cleveland, OH 44106 USA

[4] Univ Hosp, Case Med Ctr, Cleveland, OH USA

[5] Florey Inst Neurosci & Mental Hlth, Heidelberg, Vic, Australia

[6] Univ Melbourne, Florey Dept Neurosci & Mental Hlth, Melbourne, Vic, Australia

[7] Univ Southern Calif, Dept Radiol, Los Angeles, CA USA

[8] Univ Southern Calif, Dept Med, Los Angeles, CA USA

[9] Univ Southern Calif, Natl Sci Fdn Engn Res Ctr, Los Angeles, CA USA

[10] Univ Pittsburgh, Med Ctr, Dept Radiol, Pittsburgh, PA USA

[11] Univ Wisconsin, Sch Med & Publ Hlth, Dept Radiol, Madison, WI USA

[12] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Phys, Madison, WI USA

[13] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biomed Engn, Madison, WI USA

[14] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI USA

[15] Univ Wisconsin, Sch Med & Publ Hlth, Dept Emergency Med, Madison, WI USA

来源：

LANCET NEUROLOGY | 2017年 / 16卷 / 07期

基金：

美国国家卫生研究院;

关键词：

T1-WEIGHTED MR-IMAGES; HIGH-SIGNAL INTENSITY; MAGNETIC-RESONANCE IMAGES; HEALTHY RATS DIFFERENCE; DEEP CEREBELLAR NUCLEI; DENTATE NUCLEUS; GLOBUS-PALLIDUS; CONTRAST AGENTS; REPEATED ADMINISTRATIONS; BONE TISSUE;

D O I：

10.1016/S1474-4422(17)30158-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Emerging evidence has linked MRI signal changes in deep nuclei of the brain with repeated administration of gadolinium-based contrast agents. Gadolinium deposits have been confirmed in brain tissue, most notably in the dentate nuclei and globus pallidus. Although some linear contrast agents appear to cause greater MRI signal changes than some macrocyclic agents, deposition of gadolinium has also been observed with macrocyclic agents. However, the extent of gadolinium deposition varies between agents. Furthermore, the clinical significance of the retained gadolinium in the brain, if any, remains unknown. No data are available in human beings or animals to show adverse clinical effects due to the gadolinium deposition in the brain. On behalf of the International Society for Magnetic Resonance in Medicine, we present recommendations for the clinical and research use of gadolinium-based contrast agents. These recommendations might evolve as new evidence becomes available.

引用

页码：564 / 570

页数：7

共 38 条

[1] What Evidence Is There That Gadobutrol Causes Increasing Signal Intensity within the Dentate Nucleus and Globus Pallidus on Unenhanced T1W MRI in Patients with RRMS? [J].