Prenylated flavonoids from the stems and roots of Tripterygiwn wilfordii

被引：21

作者：

Chen, Yang ^{[1
]}

Zhao, Jianping ^{[2
]}

Qiu, Yixing ^{[1
]}

Yuan, Hanwen ^{[1
]}

Khan, Shabana I. ^{[2
]}

Hussain, Nusrat ^{[1
,3
]}

Choudhary, M. Iqbal ^{[3
]}

Zeng, Feng ^{[4
]}

Guo, De-An ^{[4
]}

Khan, Ikhlas A. ^{[2
]}

Wang, Wei ^{[1
]}

机构：

[1] Hunan Univ Chinese Med, Sch Pharm, Sino Pakistan TCM & Ethnomed Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China

[2] Univ Mississippi, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, University, MS 38677 USA

[3] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

[4] Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Med, Shanghai 201203, Peoples R China

来源：

FITOTERAPIA | 2017年 / 119卷

基金：

美国农业部; 中国国家自然科学基金;

关键词：

Tripterygium wilfordii; Celastraceae; Flavanone; Antimicrobial; Antimalarial; NMR; C-METHYLATED FLAVONOIDS;

D O I：

10.1016/j.fitote.2017.04.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phytochemical investigation on the stems and roots of Tripterygium wilfordii led to the isolation and characterization of three new prenylated flavanones, tripteryols A-C (1-3), along with (+/-)-5,4'-dihydroxy2'-methoxy-6',6"-dimethypyraro-(2",3":7,8)-6-methyflavanone (4), and ((2S)-5,7,4'-trihydroxy-2'-methoxy-8,5'di(3-methy1-2-buteny1)-6-methylflavanone (5). Structures of the compounds 1-5 were elucidated using spectroscopic techniques, such as UV, IR, NMR (1D and 2D), and HRESI-MS. Tripteryols B (2) was found active in the antimicrobial assay against Cryptococcus neoformans, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) with IC50 values in the range of 2.95-8.59 mu g/mL. Compounds 4 and 5 showed significant antimicrobial activities against C. neoformans, MRSA and Staphylococcus aureus with IC50 values in the range of 1.06-2.60 mu g/mL. Additionally, significant antimalarial activities of tripteryols A-B (1-2) against chloroquine-sensitive D6 and resistant W2 clones of Plasmodium falciparum were observed and none of the compounds 1-5 were cytotoxic to Vero cells.

引用

页码：64 / 68

页数：5

共 19 条

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