Optimal timing of renal replacement therapy initiation in acute kidney injury: the elephant felt by the blindmen?

被引：17

作者：

Shiao, Chih-Chung ^{[1
,2
]}

Huang, Tao-Min ^{[3
]}

Spapen, Herbert D. ^{[4
]}

Honore, Patrick M. ^{[4
]}

Wu, Vin-Cent ^{[3
,5
]}

机构：

[1] St Marys Hosp Luodong, Dept Internal Med, Div Nephrol, 160 Chong Cheng South Rd,Loudong 265, Yilan, Taiwan

[2] St Marys Jr Coll Med Nursing & Management, 100 Ln 265,Sec 2,Sanxing Rd, Sanxing Township 266, Yilan Cty, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Internal Med, Div Nephrol, 7 Chung Shan South Rd, Taipei 100, Taiwan

[4] Vrije Univ Brussel, Univ Ziekenhuis Brussel, ICU Dept, 101 Laarbeeklaan, B-1090 Brussels, Belgium

[5] Natl Taiwan Univ, Study Grp Acute Renal Failure, NSARF, Taipei, Taiwan

来源：

CRITICAL CARE | 2017年 / 21卷

关键词：

Acute kidney injury; Delayed; Early; Intensive care unit; Renal replacement therapy; Timing; CRITICALLY-ILL PATIENTS; CONTINUOUS VENOVENOUS HEMOFILTRATION; ADVERSE OUTCOMES; BIOMARKERS; FAILURE; DEFINITION; PREDICTION; MANAGEMENT; SURVIVAL; EARLIER;

D O I：

10.1186/s13054-017-1713-2

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Renal replacement therapy (RRT) is a key component in the management of severe acute kidney injury (AKI) in critically ill patients. Many cohort studies, meta-analyses, and two recent large randomized prospective trials which evaluated the relationship between the timing of RRT initiation and patient outcome remain inconclusive due to substantial differences in study design, patient population, AKI definition, and RRT indication. A cause-specific diagnosis of AKI based on current staging criteria plus a sensitive biomarker (panel) that allows creating a homogeneous study population is definitely needed to assess the impact of early versus late initiation of RRT on patient outcome.

引用

页数：7

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