The Current Status of Granulocyte-Colony Stimulating Factor to Treat Acute-on-Chronic Liver Failure

被引：19

作者：

Engelmann, Cornelius ^{[1
,2
,3
]}

Di Martino, Vincent ^{[4
]}

Kerbert, Annarein J. C. ^{[1
]}

Weil-Verhoeven, Delphine ^{[4
]}

Aehling, Niklas Friedemann ^{[2
]}

Herber, Adam ^{[2
]}

Thevenot, Thierry ^{[4
]}

Berg, Thomas ^{[2
]}

机构：

[1] UCL, Inst Liver & Digest Hlth, Liver Failure Grp, Royal Free Campus, London, England

[2] Univ Leipzig, Med Ctr, Dept Med 2, Div Hepatol, Liebigstr 21, D-04103 Leipzig, Germany

[3] Charite Univ Med Berlin, Campus Virchow Klinikum, Dept Med, Div Hepatol & Gastroenterol, Berlin, Germany

[4] Hop Jean Minjoz, Serv Hepatol & Soins Intensifs Digestifs, F-25000 Besancon, France

来源：

SEMINARS IN LIVER DISEASE | 2021年 / 41卷 / 03期

关键词：

liver cirrhosis; ACLF; alcoholic hepatitis; growth factors; STEM-CELL MOBILIZATION; G-CSF THERAPY; DECOMPENSATED CIRRHOSIS; IMPROVES SURVIVAL; CD34(+) CELLS; MACROPHAGE POLARIZATION; INFLAMMATORY RESPONSE; ALCOHOLIC HEPATITIS; PARTIAL-HEPATECTOMY; ANIMAL-MODEL;

D O I：

10.1055/s-0041-1723034

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Patients with acute-on-chronic liver failure (ACLF) have a devastating prognosis and therapeutic options are limited. Granulocyte-colony stimulating factor (G-CSF) mobilizes immune and stem cells and possess immune-modulatory and proregenerative capacities. In this review, we aim to define the current evidence for the treatment with G-CSF in end-stage liver disease. Several smaller clinical trials in patients with different severity grades of end-stage liver disease have shown that G-CSF improves survival and reduces the rate of complications. Adequately powered multicenter European trials could not confirm these beneficial effects. In mouse models of ACLF, G-CSF increased the toll-like receptor (TLR)-mediated inflammatory response which led to an increase in mortality. Adding a TLR4 signaling inhibitor allowed G-CSF to unfold its proregenerative properties in these ACLF models. These data suggest that G-CSF requires a noninflammatory environment to exert its protective properties.

引用

页码：298 / 307

页数：10

共 87 条

[1] Role of TLR2 and TLR4 in Human Neutrophil Functions Against Paracoccidioides brasiliensis [J].

Acorci-Valerio, M. J. ;

Bordon-Graciani, A. P. ;

Dias-Melicio, L. A. ;

Golim, M. de Assis ;

Nakaira-Takahagi, E. ;

de Campos Soares, A. M. V. .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2010, 71 (02) :99-108

[2] Early cirrhosis and a preserved bone marrow niche favour regenerative response to growth factors in decompensated cirrhosis [J].

Anand, Lovkesh ;

Bihari, Chhagan ;

Kedarisetty, Chandan K. ;

Rooge, Sheetalnath B. ;

Kumar, Dhananjay ;

Shubham, Smriti ;

Kumar, Guresh ;

Sahney, Amrish ;

Sharma, Manoj K. ;

Maiwall, Rakhi ;

Kumar, Anupam ;

Sarin, Shiv K. .

LIVER INTERNATIONAL, 2019, 39 (01) :115-126

[3] Acute-on-Chronic Liver Failure [J].

Arroyo, Vicente ;

Moreau, Richard ;

Jalan, Rajiv .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (22) :2137-2145

[4] Liver transplantation in the most severely ill cirrhotic patients: A multicenter study in acute-on-chronic liver failure grade 3 [J].

Artru, Florent ;

Louvet, Alexandre ;

Ruiz, Isaac ;

Levesque, Eric ;

Labreuche, Julien ;

Ursic-Bedoya, Jose ;

Lassailly, Guillaume ;

Dharancy, Sebastien ;

Boleslawski, Emmanuel ;

Lebuffe, Gilles ;

Kipnis, Eric ;

Ichai, Philippe ;

Coilly, Audrey ;

De Martin, Eleonora ;

Antonini, Teresa Maria ;

Vibert, Eric ;

Jaber, Samir ;

Herrerro, Astrid ;

Samuel, Didier ;

Duhamel, Alain ;

Pageaux, Georges-Philippe ;

Mathurin, Philippe ;

Saliba, Faouzi .

JOURNAL OF HEPATOLOGY, 2017, 67 (04) :708-715

[5] Roles of CCR2 and CCR5 for Hepatic Macrophage Polarization in Mice With Liver Parenchymal Cell-Specific NEMO Deletion [J].

Bartneck, Matthias ;

Koppe, Christiane ;

Fech, Viktor ;

Warzecha, Klaudia T. ;

Kohlhepp, Marlene ;

Huss, Sebastian ;

Weiskirchen, Ralf ;

Trautwein, Christian ;

Luedde, Tom ;

Tacke, Frank .

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2021, 11 (02) :327-347

[6] Activation of stem cells in hepatic diseases [J].

Bird, T. G. ;

Lorenzini, S. ;

Forbes, S. J. .

CELL AND TISSUE RESEARCH, 2008, 331 (01) :283-300

[7] The burden of liver disease in Europe: A review of available epidemiological data [J].

Blachier, Martin ;

Leleu, Henri ;

Peck-Radosavljevic, Markus ;

Valla, Dominique-Charles ;

Roudot-Thoraval, Francoise .

JOURNAL OF HEPATOLOGY, 2013, 58 (03) :593-608

[8] Systemic Inflammation in Decompensated Cirrhosis: Characterization and Role in Acute-on-Chronic Liver Failure [J].

Claria, Joan ;

Stauber, Rudolf E. ;

Coenraad, Minneke J. ;

Moreau, Richard ;

Jalan, Rajiv ;

Pavesi, Marco ;

Amoros, Alex ;

Titos, Esther ;

Alcaraz-Quiles, Jose ;

Oettl, Karl ;

Morales-Ruiz, Manuel ;

Angeli, Paolo ;

Domenicali, Marco ;

Alessandria, Carlo ;

Gerbes, Alexander ;

Wendon, Julia ;

Nevens, Frederik ;

Trebicka, Jonel ;

Laleman, Wim ;

Saliba, Faouzi ;

Welzel, Tania M. ;

Albillos, Agustin ;

Gustot, Thierry ;

Benten, Daniel ;

Durand, Francois ;

Gines, Pere ;

Bernardi, Mauro ;

Arroyo, Vicente .

HEPATOLOGY, 2016, 64 (04) :1249-1264

[9] A systematic literature review of the efficacy, effectiveness, and safety of filgrastim [J].

Dale, David C. ;

Crawford, Jeffrey ;

Klippel, Zandra ;

Reiner, Maureen ;

Osslund, Timothy ;

Fan, Ellen ;

Morrow, Phuong Khanh ;

Allcott, Kim ;

Lyman, Gary H. .

SUPPORTIVE CARE IN CANCER, 2018, 26 (01) :7-20

[10] Multiple Cycles of Granulocyte Colony-Stimulating Factor Increase Survival Times of Patients With Decompensated Cirrhosis in a Randomized Trial [J].

De, Arka ;

Kumari, Sunita ;

Singh, Akash ;

Kaur, Amritjyot ;

Sharma, Rattiram ;

Bhalla, Ashish ;

Sharma, Navneet ;

Kalra, Naveen ;

Singh, Virendra .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2021, 19 (02) :375-+

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