A novel intranasal Protollin™-based measles vaccine induces mucosal and systemic neutralizing antibody responses and cell-mediated immunity in mice

被引：41
|
作者：
Chabot, S
Brewer, A
Lowell, G
Plante, M
Cyr, S
Burt, DS
Ward, BJ
机构：
[1] McGill Univ, Montreal Gen Hosp, Res Inst, Dept Trop Med, Montreal, PQ H3G 1A4, Canada
[2] ID Biomed Corp Quebec, St Laurent, PQ, Canada
来源：
VACCINE | 2005年 / 23卷 / 11期
基金：
加拿大健康研究院;
关键词：
vaccine; measles; adjuvants; mucosal vaccination; neutralization; antibody; IgA; interferon-gamma;
D O I：
10.1016/j.vaccine.2004.09.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Protollin-MV is a vaccine produced by mixing split measles virus (MV) antigen with the novel adjuvant Protollin(TM) (Neisseria meningitidis outer membrane proteins non-covalently complexed with Shigella flextneri 2a lipopolysaccharide). Intranasal immunization of mice with two or three doses of Protollin-MV induces both serum IgG and mucosal IgA with strong neutralizing activity. There is a dose-dependent shift towards lower IgG(1):IgG(2a), ratios and MV-specific IFNgamma production in splenocytes. Intranasal Protollin-MV can therefore induce systemic and mucosal neutralizing antibody responses as well as elicit a balanced T-H 1/T(H)2-type response. (C) 2004 Published by Elsevier Ltd.
引用
收藏
页码：1374 / 1383
页数：10
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