Ibalizumab-uiyk as a bridge therapy for a patient with drug-resistant HIV-1 infection receiving chemotherapy: A case report

被引：5
|
作者：
Dickter, Jana K. [1 ]
Martin, Abigail L. [1 ]
Ho, Stephanie [2 ]
Ross, Justine A. [2 ]
Shouse, Geoffrey P. [3 ]
机构：
[1] City Hope Natl Med Ctr, Div Infect Dis, Dept Med, 1500 E Duarte Rd, Duarte, CA 91010 USA
[2] City Hope Natl Med Ctr, Dept Pharm Serv, 1500 E Duarte Rd, Duarte, CA 91010 USA
[3] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, 1500 E Duarte Rd, Duarte, CA 91010 USA
来源：
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2021年 / 46卷 / 04期
关键词：
AIDS; diffuse large B-cell lymphoma; drug-drug interaction chemotherapy and antiretroviral therapy; drug-resistant HIV-1 infection; HIV and lymphoma; ibalizumab-uiyk;
D O I：
10.1111/jcpt.13411
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
What is known and objective Treatment for diffuse large B-cell lymphoma (DLBCL) in persons with AIDS consists of chemotherapy alongside antiretroviral therapy (ART). To determine optimal HIV treatment, drug-drug interactions, toxic effects and ART resistance must be considered. Case description A 40-year-old man with drug-resistant HIV and DLBCL initiating chemotherapy which had drug interactions with his ART. During chemotherapy, darunavir/cobicistat was held and ibalizumab-uiyk was started to ensure he was on three active HIV medications. What is new and conclusion Ibalizumab-uiyk has no known drug-drug interactions and may be used as bridge therapy for patients with drug-resistant HIV undergoing chemotherapy.
引用
收藏
页码：1185 / 1187
页数：3
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