Synthesis and antidepressant-like profile of novel 1-aryl-3-[(4-benzyl)piperidine-1-yl]propane derivatives

被引：8

作者：

Koksal, Meric ^{[1
]}

Bilge, S. Sirri

机构：

[1] Yeditepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34755 Istanbul, Turkey

[2] Ondokuz Mayis Univ, Fac Med, Dept Pharmacol, Samsun, Turkey

来源：

ARCHIV DER PHARMAZIE | 2007年 / 340卷 / 06期

关键词：

antidepressant-like effect; aryl propane derivatives; forced swimming test; SSRI (selective serotonine reuptake inhibitors); substituted piperidine;

D O I：

10.1002/ardp.200700028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study describes the chemical synthesis and pharmacological evaluation of some new 1-aryl-3-[(4-benzyl)piperidine-1-yl]propane derivatives as antidepressants. The structures attributed to the compounds were elucidated using IR and H-1-NMR spectroscopic techniques besides elemental analysis. The antidepressant-like effect of these compounds was assessed by using the forced swimming test (FST), a validated experimental model of depression in mice. A clear antidepressant-like effect was shown for compounds 1, 2 and 4 by a significant decrease in immobility behaviour.

引用

页码：299 / 303

页数：5

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