The adjuvant effect of di-(2-ethylhexyl) phthalate is mediated through a PPARα-independent mechanism

被引：36

作者：

Larsen, Soren Thor

Nielsen, Gunnar Damgard

机构：

[1] Airway Allergy and Irritation Group, National Institute of Occupational Health

来源：

TOXICOLOGY LETTERS | 2007年 / 170卷 / 03期

关键词：

DEHP; PPAR alpha; immunological adjuvant;

D O I：

10.1016/j.toxlet.2007.03.009

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Previous studies in BALB/c mice revealed an adjuvant effect of di-(2-ethylhexyl) phthalate (DEHP) to simultaneously administered ovalbumin. DEHP is the most commonly used phthalate plasticizer. In vivo formed metabolites of DEHP are peroxisome-proliferator-activated receptor (PPAR) ligands, a group of chemicals that may have immunomodulatory properties. To study whether the PPAR alpha receptor was involved in the adjuvant effect of DEHP, PPAR alpha-deficient 129/Sv mice were exposed intraperitoneally to a mixture of OVA and DEHP, and the OVA-specific IgE, IgG1 and IgG2a responses were compared to the corresponding responses in the wild-type strain. The study showed that the adjuvant mechanism of DEHP is mediated through a PPAR alpha-independent mechanism. Compared to mice only given OVA, DEHP induced highly increased levels of OVA-specific IgG1 and IgG2a, both in the wild-type and in the PPARa knock-out strains, indicating that DEHP is a mixed Th1/Th2 adjuvant. (C) 2007 Published by Elsevier Ireland Ltd.

引用

页码：223 / 228

页数：6

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