Temperature and density evolution during compaction of a capsule shaped tablet

被引：38

作者：

Klinzing, Gerard R. ^{[1
]}

Zavaliangos, Antonios ^{[1
]}

Cunningham, John ^{[2
]}

Mascaro, Tracey ^{[2
]}

Winstead, Denita ^{[2
]}

机构：

[1] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA

[2] Johnson & Johnson Pharmaceut Res & Dev, Spring House, PA 19477 USA

来源：

COMPUTERS & CHEMICAL ENGINEERING | 2010年 / 34卷 / 07期

基金：

美国国家科学基金会;

关键词：

Tableting; Temperature; Compaction; Finite element simulation; Density distribution; PRAGER-CAP MODEL; PHARMACEUTICAL POWDERS; MECHANICAL-BEHAVIOR; SIZE; VALIDATION; SIMULATION; STRENGTH; FRICTION; FLOW;

D O I：

10.1016/j.compchemeng.2010.04.012

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

This paper continues the effort to validate the finite element based analysis of tableting. A three-dimensional capsule shaped tablet is studied using a Drucker-Prager cap constitutive model and a coupled thermomechanical analysis. Predictions of the model for the internal distribution of porosity and temperature are found to be in agreement with X-ray microtomography measurements of relative density and infrared camera measurements of surface temperatures of the ejected tablet. The fact that the model is calibrated using data from a cylindrical flat-faced tablet which can predict the compaction of a completely different shape proves the capability offered by finite element analysis In addition, this method demonstrates the role it can play in the optimization of tableting operations in the spirit of quality by design principles. (C) 2010 Elsevier Ltd. All rights reserved

引用

页码：1082 / 1091

页数：10

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