Oroxylin A maintains the colonic mucus barrier to reduce disease susceptibility by reconstituting a dietary fiber-deprived gut microbiota

被引：37

作者：

Bai, Dongsheng ^{[1
]}

Sun, Tifan ^{[1
]}

Zhao, Jiawei ^{[1
]}

Du, Jiaying ^{[1
]}

Bu, Xiumin ^{[1
]}

Cao, Wangjia ^{[1
]}

Zhao, Yue ^{[1
]}

Lu, Na ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Physiol, State Key Lab Nat Med,Jiangsu Key Lab Carcinogene, 24 Tongjiaxiang, Nanjing 210009, Peoples R China

来源：

CANCER LETTERS | 2021年 / 515卷

基金：

中国国家自然科学基金;

关键词：

Dietary fiber; Oroxylin A; Mucus layer; Gut microbiota; Eubacterium coprostanoligenes; HEALTH; ASTHMA; LAYERS; MUCIN;

D O I：

10.1016/j.canlet.2021.05.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dietary fiber intake helps to maintain gut homeostasis. Fiber deficiency causes commensals to utilize mucins as an energy source to destroy mucus layer, thus promoting susceptibility to inflammatory bowel disease. Here, we reported that oroxylin A, a natural flavonoid, ameliorated low-grade colonic inflammation caused by fiber deficiency, alleviated colitis, and further prevented colitis-associated colon cancer in mice. The antiinflammatory effect of oroxylin A was due to its alteration of gut microbiota. We found that the levels of Eubacterium coprostanoligenes was significantly increased by oroxylin A and the colonized Eubacterium coprostanoligenes significantly protected against colitis and carcinogenesis in colon of mice. Together, our results in this study suggest that oroxylin A may reduce the susceptibility to intestinal diseases by increasing the level of Eubacterium coprostanoligenes which could provide a therapeutic alternation for the treatment of intestinal diseases.

引用

页码：73 / 85

页数：13

共 26 条

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