Involvement of nitric oxide in Parkinson's disease: Emphasis on sex difference in prevalence

被引:0
作者
Taskiran, D [1 ]
Nazliel, B
Irkec, C
Kutay, FZ
Pogun, S
机构
[1] Ege Univ, Ctr Brain Res, Izmir, Turkey
[2] Ege Univ, Sch Med, Dept Physiol, Izmir, Turkey
[3] Ege Univ, Sch Med, Dept Biochem, Izmir, Turkey
[4] Gazi Univ, Sch Med, Dept Neurol, Ankara, Turkey
关键词
Parkinson's disease; nitric oxide; neurodegeneration; sex difference;
D O I
10.1002/nrc.10068
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Parkinson's disease (PD) is characterized by severe movement disorders. Excessive production of reactive oxygen species has been implicated as a possible mediator of neurodegenerative changes in nigrostriatal neurons in PD. Nitric oxide (NO) has received substantial attention among pathophysiological factors underlying glutamate neurotoxicity in neurodgenerative disorders including PD. PD is more prevalent in men than in women by an approximate 3:2 ratio; the nitrergic systems are also more active in males than females. In this study, NO2-+NO3- (stable metabolites of NO) levels were determined in sera of PD patients (n=20) and control subjects (n=16). NO2-+NO3- Levels were higher in PD patients compared to controls, and in males compared to females. Furthermore, there was a correlation between age and NO metabolites in females but not in males. These data support a role for NO in PD and provide further evidence for sex differences in NO activity that may underlie neurodegenerative disorders.
引用
收藏
页码:135 / 142
页数:8
相关论文
共 50 条
[31]   Nitric oxide and nitric oxide synthase in Huntington's disease [J].
Deckel, AW .
JOURNAL OF NEUROSCIENCE RESEARCH, 2001, 64 (02) :99-107
[32]   Reciprocal Upshot of Nitric Oxide, Endoplasmic Reticulum Stress, and Ubiquitin Proteasome System in Parkinson's Disease Pathology [J].
Tiwari, Shubhangini ;
Singh, Sarika .
NEUROSCIENTIST, 2021, 27 (04) :340-354
[33]   Levodopa-induced dyskinesias in Parkinson's disease increase cerebrospinal fluid nitric oxide metabolites' levels [J].
Santos-Lobato, Bruno L. ;
Bortolanza, Mariza ;
Pinheiro, Lucas Cesar ;
Batalhao, Marcelo E. ;
Pimentel, Angela V. ;
Capellari-Carnio, Evelin ;
Del-Bel, Elaine A. ;
Tumas, Vitor .
JOURNAL OF NEURAL TRANSMISSION, 2022, 129 (01) :55-63
[34]   Association of a neuronal nitric oxide synthase gene polymorphism with levodopa-induced dyskinesia in Parkinson's disease [J].
Santos-Lobato, Bruno Lopes ;
Borges, Vanderci ;
Ferraz, Henrique Ballalai ;
Mata, Ignacio Fernandez ;
Zabetian, Cyrus P. ;
Tumas, Vitor .
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2018, 74 :86-90
[35]   Levodopa-induced dyskinesias in Parkinson’s disease increase cerebrospinal fluid nitric oxide metabolites’ levels [J].
Bruno L. Santos-Lobato ;
Mariza Bortolanza ;
Lucas César Pinheiro ;
Marcelo E. Batalhão ;
Ângela V. Pimentel ;
Evelin Capellari-Carnio ;
Elaine A. Del-Bel ;
Vitor Tumas .
Journal of Neural Transmission, 2022, 129 :55-63
[36]   Synergistic inhibition of respiration in brain mitochondria by nitric oxide and dihydroxyphenylacetic acid (DOPAC) Implications for Parkinson's disease [J].
Nunes, C ;
Almeida, L ;
Laranjinha, J .
NEUROCHEMISTRY INTERNATIONAL, 2005, 47 (03) :173-182
[37]   Role of Nitric Oxide Synthases in Parkinson’s Disease: A Review on the Antioxidant and Anti-inflammatory Activity of Polyphenols [J].
Katia Aquilano ;
Sara Baldelli ;
Giuseppe Rotilio ;
Maria Rosa Ciriolo .
Neurochemical Research, 2008, 33 :2416-2426
[38]   Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of β-Amyloid Precursor Protein [J].
Ayton, Scott ;
Lei, Peng ;
Hare, Dominic J. ;
Duce, James A. ;
George, Jessica L. ;
Adlard, Paul A. ;
McLean, Catriona ;
Rogers, Jack T. ;
Cherny, Robert A. ;
Finkelstein, David I. ;
Bush, Ashley I. .
JOURNAL OF NEUROSCIENCE, 2015, 35 (08) :3591-3597
[39]   Role of Nitric Oxide Synthases in Parkinson's Disease: A Review on the Antioxidant and Anti-inflammatory Activity of Polyphenols [J].
Aquilano, Katia ;
Baldelli, Sara ;
Rotilio, Giuseppe ;
Ciriolo, Maria Rosa .
NEUROCHEMICAL RESEARCH, 2008, 33 (12) :2416-2426
[40]   Nitric Oxide Modulation of the Basal Ganglia Circuitry: Therapeutic Implication for Parkinson's Disease and Other Motor Disorders [J].
Pierucci, Massimo ;
Galati, Salvatore ;
Valentino, Mario ;
Di Matteo, Vincenzo ;
Benigno, Arcangelo ;
Pitruzzella, Alessandro ;
Muscat, Richard ;
Di Giovanni, Giuseppe .
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2011, 10 (07) :777-791