Involvement of nitric oxide in Parkinson's disease: Emphasis on sex difference in prevalence

被引:0
作者
Taskiran, D [1 ]
Nazliel, B
Irkec, C
Kutay, FZ
Pogun, S
机构
[1] Ege Univ, Ctr Brain Res, Izmir, Turkey
[2] Ege Univ, Sch Med, Dept Physiol, Izmir, Turkey
[3] Ege Univ, Sch Med, Dept Biochem, Izmir, Turkey
[4] Gazi Univ, Sch Med, Dept Neurol, Ankara, Turkey
关键词
Parkinson's disease; nitric oxide; neurodegeneration; sex difference;
D O I
10.1002/nrc.10068
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Parkinson's disease (PD) is characterized by severe movement disorders. Excessive production of reactive oxygen species has been implicated as a possible mediator of neurodegenerative changes in nigrostriatal neurons in PD. Nitric oxide (NO) has received substantial attention among pathophysiological factors underlying glutamate neurotoxicity in neurodgenerative disorders including PD. PD is more prevalent in men than in women by an approximate 3:2 ratio; the nitrergic systems are also more active in males than females. In this study, NO2-+NO3- (stable metabolites of NO) levels were determined in sera of PD patients (n=20) and control subjects (n=16). NO2-+NO3- Levels were higher in PD patients compared to controls, and in males compared to females. Furthermore, there was a correlation between age and NO metabolites in females but not in males. These data support a role for NO in PD and provide further evidence for sex differences in NO activity that may underlie neurodegenerative disorders.
引用
收藏
页码:135 / 142
页数:8
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