Cancer stem cells - important players in tumor therapy resistance

被引：204

作者：

Colak, Selcuk

Medema, Jan P.

机构：

[1] Univ Amsterdam, Acad Med Ctr, Ctr Expt Mol Med, LEXOR Lab Expt Oncol & Radiobiol, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Canc Genom Ctr, NL-1105 AZ Amsterdam, Netherlands

来源：

FEBS JOURNAL | 2014年 / 281卷 / 21期

关键词：

cancer; cancer stem cell; chemotherapy; resistance; tumor-initiating cells; HUMAN HEMATOPOIETIC STEM; ACUTE MYELOID-LEUKEMIA; SELF-RENEWAL; IN-VITRO; PROSPECTIVE IDENTIFICATION; PREFERENTIAL EXPRESSION; ALDEHYDE DEHYDROGENASE; MULTIDRUG-RESISTANCE; INITIATING CELLS; DOSE-ESCALATION;

D O I：

10.1111/febs.13023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resistance to tumor therapy is an unsolved problem in cancer treatment. A plethora of studies have attempted to explain this phenomenon and many mechanisms of resistance have been suggested over recent decades. The concept of cancer stem cells (CSCs), which describes tumors as hierarchically organized, has added a new level of complexity to therapy failure. CSCs are the root of cancers and resist chemo- and radiotherapy, explaining cancer recurrence even many years after therapy is ended. This review discusses briefly CSCs in cancers, gives an overview of the role of CSCs in therapy resistance, and discusses the potential means of targeting these therapy-resistant tumor cells.

引用

页码：4779 / 4791

页数：13

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