Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature

被引：5

作者：

Afonso, Carolina ^{[1
]}

Roque, Adriana ^{[1
]}

Almeida, Catia ^{[1
]}

Pimentao, Maria Beatriz ^{[2
]}

Juliao, Maria Jose ^{[2
]}

Silva, Rodolfo ^{[3
]}

Geraldes, Catarina ^{[1
]}

Gomes, Marilia ^{[1
]}

机构：

[1] Hosp Univ Coimbra, Ctr Hosp & Univ Coimbra, Hematol Unit, Coimbra, Portugal

[2] Hosp Univ Coimbra, Ctr Hosp & Univ Coimbra, Pathol Unit, Coimbra, Portugal

[3] Hosp Univ Coimbra, Ctr Hosp & Univ Coimbra, Nucl Med Unit, Coimbra, Portugal

来源：

CASE REPORTS IN HEMATOLOGY | 2022年 / 2022卷

关键词：

CLASSICAL HODGKIN LYMPHOMA; B-CELL LYMPHOMA; RHEUMATOID-ARTHRITIS; CLINICOPATHOLOGICAL ANALYSIS; FOCUS;

D O I：

10.1155/2022/7178065

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug commonly used for the treatment of autoimmune diseases, is an immunosuppressive agent frequently reported to be associated with LPD. MTX-associated LPD (MTX-LPD) includes a spectrum of lymphocytic proliferations, ranging from polyclonal hyperplasia to malignant lymphoma. MTX-LPD diagnosis can be challenging, as signs and symptoms are often nonspecific and may overlap with those of several other conditions, including exacerbation of the underlying autoimmune disease. Spontaneous regression of LPD after MTX discontinuation is characteristic of MTX-LPD, therefore avoiding chemotherapeutic intervention in a significant proportion of patients. Other cases, however, should receive chemotherapy.

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页数：6

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共 24 条

[11] Spontaneous remission of "methotrexate-associated lymphoproliferative disorders" after discontinuation of immunosuppressive treatment for autoimmune disease. Review of the literature [J].

Rizzi, Rita ;

Curci, Paola ;

Delia, Mario ;

Rinaldi, Erminia ;

Chiefa, Antonia ;

Specchia, Giorgina ;

Liso, Vincenzo .

MEDICAL ONCOLOGY, 2009, 26 (01) :1-9

[12] Immune response in LPD during methotrexate administration MTX-LPD in rheumatoid arthritis patients [J].

Saito, Shuntaro ;

Takeuchi, Tsutomu .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2019, 59 (04) :145-155

[13] EBV-positive B-cell lymphomas and lymphoproliferative disorders: Review from the perspective of immune escape and immunodeficiency [J].

Satou, Akira ;

Nakamura, Shigeo .

CANCER MEDICINE, 2021, 10 (19) :6777-6785

[14] Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV plus AVD) [J].

Sekiguchi, Yasunobu ;

Iizuka, Hiroko ;

Takizawa, Haruko ;

Sugimoto, Keiji ;

Sakajiri, Sakura ;

Inano, Tadaaki ;

Fukuda, Yasutaka ;

Shirane, Syuichi ;

Hamano, Yasuharu ;

Tomite, Shigeki ;

Izumi, Hiroshi ;

Okubo, Mitsuo ;

Nakamura, Noriko ;

Sawada, Tomohiro ;

Sekiguchi, Naoya ;

Noguchi, Masaaki .

INTERNAL MEDICINE, 2020, 59 (17) :2165-2171

[15] Clinicopathological evaluation of methotrexate-associated lymphoproliferative disorders with special focus on Epstein-Barr virus-positive mucocutaneous lesions [J].

Shiraiwa, Sawako ;

Kikuti, Yara Yukie ;

Carreras, Joaquim ;

Hara, Ryujiro ;

Aoyam, Yasuyuki ;

Ogiya, Daisuke ;

Suzuki, Rikio ;

Toyosaki, Masako ;

Ohmachi, Ken ;

Ogawa, Yoshiaki ;

Kawada, Hiroshi ;

Sato, Shinji ;

Nakamura, Naoya ;

Ando, Kiyoshi .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2020, 60 (04) :159-168

[16] Clinical characteristics of methotrexate-associated lymphoproliferative disorders: relationship between absolute lymphocyte count recovery and spontaneous regression [J].

Takanashi, Satoshi ;

Aisa, Yoshinobu ;

Ito, Chisako ;

Arakaki, Hideki ;

Osada, Yuki ;

Amano, Yuichiro ;

Hirano, Motoharu ;

Nakazato, Tomonori .

RHEUMATOLOGY INTERNATIONAL, 2017, 37 (10) :1629-1633

[17] Nivolumab for Methotrexate-associated Classic Hodgkin's Lymphoma in a Rheumatoid Arthritis Patient [J].

Tanaka, Keisuke ;

Kuboki, Mai ;

Koi, Satoshi ;

Toyota, Shigeo .

INTERNAL MEDICINE, 2020, 59 (06) :829-833

[18] Clinical management for other iatrogenic immunodeficiency-associated lymphoproliferative disorders [J].

Tokuhira, Michihide ;

Tamaru, Jun-ichi ;

Kizaki, Masahiro .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2019, 59 (02) :72-92

[19] Clinicopathologic investigation of methotrexate-induced lymphoproliferative disorders, with a focus on regression [J].

Tokuhira, Michihide ;

Saito, Shuntaro ;

Okuyama, Ayumi ;

Suzuki, Katsuya ;

Higashi, Morihiro ;

Momose, Shuji ;

Shimizu, Takayuki ;

Mori, Takehiko ;

Anan-Nemoto, Tomoe ;

Amano, Koichi ;

Okamoto, Shinichiro ;

Takeuchi, Tsutomu ;

Tamaru, Jun-Ichi ;

Kizaki, Masahiro .

LEUKEMIA & LYMPHOMA, 2018, 59 (05) :1143-1152

[20] Methotrexate-associated lymphoproliferative disorder in the stomach and duodenum: a case report [J].

Toyonaga, Haruka ;

Fukushima, Masashi ;

Shimeno, Naoto ;

Inokuma, Tetsuro .

BMC GASTROENTEROLOGY, 2019, 19 (1)